Registration Dossier
Registration Dossier
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EC number: 254-911-5 | CAS number: 40412-06-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 Oct 2017 - 07 Dec 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
Test material
- Reference substance name:
- 2-(2-thienyl)ethyl toluene-p-sulphonate
- EC Number:
- 254-911-5
- EC Name:
- 2-(2-thienyl)ethyl toluene-p-sulphonate
- Cas Number:
- 40412-06-4
- Molecular formula:
- C13H14O3S2
- IUPAC Name:
- 2-(thiophen-2-yl)ethyl 4-methylbenzene-1-sulfonate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Physical appearance: white to off-white powder
- Test item storage: at room temperature
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 11.3 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 6.5
- Remarks on result:
- other: average of two runs
- Details on results:
- Mean concentration in the water samples (n=10) obtained at the flowrate of 24 mL/h was 11.4 mg/L. CV= 1.1%.
Mean concentration in the water samples (n=10) obtained at the flowrate of 12 mL/h was 11.1 mg/L. CV= 0.71%.
The maximum difference on the mean values at both flow rates was ≤ 30% (i.e. 2.5%). Average of two runs: 11.3 mg/L.
The coefficient of variation (CV) (n=10) was ≤ 30% at both flow rates. It demonstrated that the system was in equilibrium at all flow rates. The maximum difference on the mean values at both flow rates was ≤ 30%.
Any other information on results incl. tables
No test substance was detected in the samples from the blank column.
Applicant's summary and conclusion
- Conclusions:
- The water solubility at 20°C was determined to be 11.3 mg/L.
- Executive summary:
The water solubility of the substance was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.
Quantification was performed by UPLC-UV. The water solubility was calculated as the average of two runs (24 mL/h and 12 mL/h).
The water solubility at 20°C was determined to be 11.3 mg/L. The pH of the aqueous samples was 6.4-6.5.
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