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EC number: 260-086-2 | CAS number: 56271-94-4
No reproduction toxicity was observed up to the highest dose level tested (1000 mg/kg).
No treatment-related changes were noted in the reproductive parameters examined (i.e. mating
and fertility indices, precoital time, number of implantation sites, estrous cycle,
spermatogenic profiling, and histopathological examination of reproductive organs).
No developmental toxicity was observed up to the highest dose level tested (1000 mg/kg).
No treatment-related changes were noted in the developmental parameters examined (i.e.
gestation, viability and lactation indices, duration of gestation, parturition, sex ratio, litter
size, clinical signs, body weight, anogenital distance (PND 1), areola/nipple retention
(PND 13 males), T4 thyroid hormone levels (PND 14-16) and macroscopic examination).
No effects on fertility or developmental toxicity were observed at the limit dose (1000 mg/kg bw/day) . The criteria for classification for Toxicity to reproduction in accordance with 1272/2008/EC are not met.
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