Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
19 December 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Due to the low solubility of the test material in water and octanol, formal testing was not possible. The sponsor has therefore provided the estimation of log Pow being equal -1.01. This is the ChemAxon ‘Consenus’ method which uses a consensus model built on the ChemAxon, Klopman et al. models and the PhysProp database.
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor and G316533
- Expiration date of the lot/batch: 25 March 2018
- Purity test date: 22 August 2017
Key result
Type:
log Pow
Partition coefficient:
-1.01
Remarks on result:
other: estimated value
Details on results:
Due to the low solubility of the test material in water and octanol, formal testing was not possible. The sponsor has therefore provided the estimation of log Pow being equal -1.01. This is the ChemAxon ‘Consenus’ method which uses a consensus model built on the ChemAxon, Klopman et al. models and the PhysProp database.
Conclusions:
Due to the low solubility of the test material in water and octanol, formal testing was not possible. The sponsor has therefore provided the estimation of log Pow being equal -1.01. This is the ChemAxon ‘Consenus’ method which uses a consensus model built on the ChemAxon, Klopman et al. models and the PhysProp database.

Description of key information

Due to the low solubility of the test material in water and octanol, formal testing was not possible. The sponsor has therefore provided the estimation of log Pow being equal -1.01. This is the ChemAxon ‘Consenus’ method which uses a consensus model built on the ChemAxon, Klopman et al. models and the PhysProp database.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.01

Additional information