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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-05-07 to 2018-05-29
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
refer to Principles of method if other than guideline
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
refer to Principles of method if other than guideline
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
refer to Principles of method if other than guideline
Principles of method if other than guideline:
A miscibility test was carried out to evaluate the solubility of the test item in water. Although, this procedure deviates from the guideline, it is considered scientifically valid.
GLP compliance:
yes (incl. certificate)
Type of method:
other: miscibility test with visual inspection
Key result
Temp.:
20 °C
pH:
>= 11.7 - <= 13.2
Remarks on result:
completely miscible

The miscibility of the test item with ultrapure water was investigated at three different ratios. Single-phase clear solution was observed at all tested ratios, thus, the test item is considered to be miscible with water.

 

Test item : water ratio

Volume of Test Item

Volume of Water

Observation

pH

1 : 9

1 mL

9 mL

Single-phase clear solution

11.7

9 : 1

9 mL

1 mL

Single-phase clear solution

13.2

1 : 1

5 mL

5 mL

Single-phase clear solution

12.6

 

Conclusions:
The test item is completely miscible in water at different ratios.
Executive summary:

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could be prepared, therefore, the standard methods for determination of the water solubility are technically not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual detection. The test item was mixed with ultrapure water in ratios 1 :1, 1 : 9 and 9 : 1. After sonication and vigorous shaking the solubility was visually detected. The pH of each sample was recorded. The test substance was determined to be completely miscible in water at ambient temperature.

Description of key information

The test item is completely miscible in water at ambient temperature. For further risk assessment a maximum default value of 100000 mg/L was used.

Key value for chemical safety assessment

Water solubility:
100 000 mg/L
at the temperature of:
20 °C

Additional information

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could be prepared, therefore, the standard methods for determination of the water solubility are technically not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual detection. The test item was mixed with ultrapure water in ratios 1 :1, 1 : 9 and 9 : 1. After sonication and vigorous shaking the solubility was visually detected. The pH of each sample was recorded. The test substance was determined to be completely miscible in water at ambient temperature.