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Environmental fate & pathways

Adsorption / desorption

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Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
09 February 2010 – 17 March 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Remarks:
Read-across to QSAR calculation. Log Kow of test substance (>6) may be outside of applicability domain of QSAR (1 - 7.5). Structure of test substance is outside of applicability domain of QSAR (only molecules containing C, H, F, Cl, Br and I atoms are suited for calculations, test substance contains O atoms). No validation (QMRF and QPRF) provided.
Justification for type of information:
The log Kocwas calculated using the QSAR for predominantly hydrophobics given in Technical Guidance document in support of Commission Directive 93/67/on Risk Assessment for new notified substances and Commission Regulation (EC) 1488/94 on Risk Assessment for existing substances. This QSAR was used because Standolized linseed oil is a hydrophobic compound:
Cross-reference
Reason / purpose:
reference to same study
Reference
Endpoint:
adsorption / desorption: screening
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Justification for type of information:
See attached justification
Reason / purpose:
read-across source

The log Kocwas calculated using the QSAR for predominantly hydrophobics given in Technical Guidance document in support of Commission Directive 93/67/on Risk Assessment for new notified substances and Commission Regulation (EC) 1488/94 on Risk Assessment for existing substances. This QSAR was used because Standolized linseed oil is a hydrophobic compound:

Log Koc = 0.81 log Pow + 0.10

The partition coefficient, Pow, of Standolized linseed oil was determined to be >1x106 (log Pow >6) using the estimation method (section 4.7). Using this log Pow value and the above given equation, log Kocof Standolized linseed oil was calculated to be > 4.96.

Validity criteria fulfilled:
not applicable
Conclusions:
log Koc of Standolized soybean oil was calculated to be > 4.96 by a QSAR method via read across to linseed oil

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to
Guideline:
other: Technical Guidance document in support of Commission Directive 93/67/EEC on Risk Assessment for new notified substances and Commission Regulation (EC) 1488/94 on Risk Assessment for existing substances. Part III, pages 532 - 543.
Deviations:
no
Principles of method if other than guideline:
The adsorption coefficient (Koc) cannot be determined using the HPLC method since Standolized linseed oil does not dissolve in water, methanol and acetonitrile at a concentration of 1 g/L required for refractive index detection.
Due to its low solubility in aqueous solvents, also OECD106 is not applicable.
As an alternative, the adsorption coefficient was determined using a quantitative structure activity relationship (QSAR).
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Standolized linseed oil
- Substance type: Hazy yellow/brown viscous liquid
- Physical state: liquid
- Analytical purity: treated as 100% pure
- Lot/batch No.: 09.317.013
- Expiration date of the lot/batch: 21 December 2010
- Stability under test conditions: stable
- Storage condition of test material: At room temperature in the dark
- Other: -
Radiolabelling:
no

Results and discussion

Adsorption coefficient
Key result
Type:
log Koc
Value:
> 4.96
Remarks on result:
other: value derived from equation

Any other information on results incl. tables

The log Kocwas calculated using the QSAR for predominantly hydrophobics given in Technical Guidance document in support of Commission Directive 93/67/on Risk Assessment for new notified substances and Commission Regulation (EC) 1488/94 on Risk Assessment for existing substances. This QSAR was used because Standolized linseed oil is a hydrophobic compound:

Log Koc = 0.81 log Pow + 0.10

The partition coefficient, Pow, of Standolized linseed oil was determined to be >1x106 (log Pow >6) using the estimation method (section 4.7). Using this log Pow value and the above given equation, log Kocof Standolized linseed oil was calculated to be > 4.96.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
log Koc of Standolized linseed oil was calculated to be > 4.96 via a QSAR method.