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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
dynamic method
Key result
Test no.:
#1
Temp.:
ca. 50 °C
Vapour pressure:
<= 0.001 Pa
Remarks on result:
not determinable because of methodological limitations
Key result
Test no.:
#2
Temp.:
ca. 20 °C
Vapour pressure:
< 0.001 Pa
Remarks on result:
not determinable because of methodological limitations
Key result
Vapour pressure:
<= 0.001 Pa

The mass of sample weighed for each assay was reported in the table below. The sample was placed in a Knudsen effusion cell. Then the cell was placed in the apparatus.

 

Assay No.

Test temperature

t(°C)

Mass of test item

weighed
(mg)

dm/dT

(mg/min)

Knudsen effusion cell aperture size(µm)

Taken into account or not

1

50

9.24

/*

279.9

Yes

2

80

7.07

/*

279.9

Yes

* the loss of mass was not measured as no linear part was recorded.

 

For the assay No. 1 a small loss of weight, representing about 2% of the initial mass, was recorded at 50 °C but without any linear part. The slope of the loss of mass was not constant and decreased continuously until becoming close to zero.No degradation of the test item was observed after the experiment; the powder remained slightly yellow.

The temperature was increased up to 80 °C and the results were similar.

The loss of mass observed at the beginning of the assays is not significant and can correspond to the evaporation of volatile impurities or to the stabilisation of the mass.

Conclusions:
The vapour pressure of the test item was considered to be lower than 10-3 Pa at 50 °C and as a consequence largely lower than 10-3 Pa at 20 °C.

Description of key information

The vapour pressure of the test item was considered to be lower than 10-3 Pa at 50 °C and as a consequence largely lower than 10-3 Pa at 20 °C (OECD 104)

Key value for chemical safety assessment

Additional information

Testing was conducted according to a scientifically valid and accepted method (OECD 104).

The value of 10-3 Pa corresponds to the minimal limit of pressure determined by the lab apparatus.

It was not possible to find another appropriate method to measure the vapour pressure of this multiconstituents substance with a relatively low vapour pressure (lower than 10-3 Pa).