Reaction product of zirconium (IV) dioxide and zirconium (IV) dicarbonate with nitric acid

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vitro

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is a strong acid (pH ≤2.0) or base (pH =>11.5)

Justification for type of information:

The substance has a pH of 1.2, therefore it can be considered to be corrosive
In-vitro methods are not fully validated for inorganic salts

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Justification for type of information:

In-house data assessment.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

Solubility at range of pH was investigated as has relevance for environmental and toxicological assessments.

GLP compliance:

no

Type of method:

other: Observations

Specific details on test material used for the study:

Batch number of test material: C-04-3584

Key result

Water solubility:

ca. 1 000 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

ca. 1.2

Remarks on result:

completely miscible

Remarks:

pH unadjusted

Water solubility:

> 50 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

20 °C

pH:

ca. 1.5

Remarks on result:

other: pH buffered for evaluation of solubility at different pH

Conclusions:

The solubility is pH dependant with reduced solublity at pH 5 or more, suggesting formation of hydroxide / oxide
The substance supplied is typically in acidic solution