Registration Dossier
Registration Dossier
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EC number: 202-417-5 | CAS number: 95-41-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Physical Appearance: Almost colourless to yellow-brown liquid
- Date of Expiry: 01-08-2018
- Storage Condition: Ambient (21 to 29°C) - Key result
- Water solubility:
- 252.21 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 5.5
- Details on results:
- - System suitability: System suitability meets the acceptance criterion as the % RSD obtained was 0.73% to 4.70% which is less than 5.0%.
- Specificity: Specificity meets the acceptance criterion for the test substance as the interference obtained for diluent was 4.86% which is < 30% of the standard response at LOQ.
- Limit of Detection (LOD) and Limit of Quantification (LOQ): The LOD was determined at 9.45 mg/L and LOQ was determined at 23.61 mg/L
- Linearity: Linearity meets the acceptance criterion as the correlation coefficient obtained was 0.9992 to 0.9999 which is > 0.99.
- Accuracy (% Recovery) and Precision (% RSD): Recovery meets the acceptance criterion as the % recovery obtained was 102.86% for LOQ and 96.59% for 10 LOQ which is within the range 70% to 110% of the nominal concentration at each fortification level. Precision meets the acceptance criterion as the % RSD obtained was 3.20% for LOQ and 6.00% for 10 LOQ which is < 20%.
- Preliminary Test: Preliminary result indicated that the test item had a solubility of more than 10^-2 g/L in milli-Q water.
- Definitive Test: The solubility of the test substance in Milli-Q water was determined to be 242.37 mg/L for 24 hours, 258.44 mg/L for 48 hours and 255.83 mg/L for 72 hours at 20°C.
Reference
Description of key information
The water solubility of the test substance is 252.21 mg/L (OECD 105 and GLP).
Key value for chemical safety assessment
- Water solubility:
- 252.21 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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