Fatty acids, C16 and C18-20 (even numbered, unsaturated), 2-ethylhexyl esters

Endpoint summary

Additional information

The water solubility of Fatty acids, C12-20 and C12-20-unsatd., 2-ethylhexyl esters, is estimated to be <0.000592 mg/L. This substance can therefore be considered as highly insoluble, see section 4.8 for details. According to Annex VIII a short-term test on fish is required unless there are mitigating factors such as the test substance is insoluble, this is the case for Fatty acids, C12-20 and C12-20-unsatd., 2-ethylhexyl esters. Therefore, no aquatic toxicity studies are required.

The following summary is taken from the OECD SIDS Initial Assessment Report for SIAM 22, 18 -21 April 2006 for Epoxidized Oils and Derivatives:

Effects are not expected to be observed below the water solubility of these materials (i.e. including Fatty acids, C14 -22, 2ethylhexyl esters, epoxidised as equivalent to ETP). Based on the physicochemical properties of the category members (very low water solubility, log Kow values >6.2, and readily biodegradable), the substances are unlikely to be bioavailable to aquatic organisms in acute aquatic testing. In preparation to conduct a chronic Daphnia study it was demonstrated that there was no water soluble test substance detected above 0.05 mg EODA/L in a Water Accommodated Fraction (WAF) prepared from a loading of 100 mg/L. Therefore, considering the structure and low water solubility of EODA, it was concluded that the WAF is not likely to exert acute measurable effects on daphnids, and a chronic test would not be likely to provide meaningful, quantitative information on such effects. The option of conducting the chronic daphnia test with another member of the EOD family was considered, however similar results are expected from the WAF preparations for these poorly soluble substances. Further laboratory investigation of the chronic toxicity of this substance to aquatic organisms is therefore deemed not necessary.