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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 Feb to 29 Mar 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
yes (incl. certificate)
Remarks:
Department of Health of the Government of the United Kingdom, Medicines and Heathcare products Regulatory Agency (MHRA)
Type of method:
method to determine freezing temperature
Melting / freezing pt.:
< -20 °C

Results

Cooling data for Determinations 1 and 2 are shown in the following tables.

Table 1: Determination 1

Time (s)

Temperature (°C)

Time (s)

Temperature (°C)

Time (s)

Temperature (°C)

0

20.5

480

-2.0

960

-14.5

30

19.0

510

-3.0

990

-15.0

60

17.0

540

-4.0

1020

-15.5

90

15.0

570

-5.0

1050

-16.5

120

13.5

600

-6.0

1080

-17.0

150

12.0

630

-7.0

1110

-17.0

180

10.5

660

-7.5

1140

-17.5

210

9.0

690

-8.5

1170

-18.0

240

7.5

720

-9.5

1200

-18.5

270

6.0

750

-10.0

1230

-19.0

300

4.5

780

-11.0

1260

-19.0

330

3.5

810

-11.5

1290

-19.5

360

2.5

840

-12.0

1320

-20.0

390

1.5

870

-13.0

1350

-20.0

420

0.0

900

-13.5

1380

-20.5

450

-1.0

930

-14.0

1410

-21.0

Observations: The test item did not change during cooling.

Result: Freezing temperature: <-20 °C (<253 K)

 

Table 2: Determination 2

Time (s)

Temperature (°C)

Time (s)

Temperature (°C)

Time (s)

Temperature (°C)

0

22.0

510

-2.5

1020

-15.5

30

21.0

540

-3.5

1050

-16.0

60

19.0

570

-4.5

1080

-16.0

90

17.5

600

-5.5

1110

-16.5

120

15.5

630

-6.5

1140

-17.0

150

14.0

660

-7.0

1170

-17.5

180

12.0

690

-8.0

1200

-18.0

210

10.5

720

-9.0

1230

-18.5

240

9.0

750

-9.5

1260

-18.5

270

7.5

780

-10.5

1290

-19.0

300

6.5

810

-11.0

1320

-19.5

330

5.0

840

-12.0

1350

-20.0

360

3.5

870

-12.5

1380

-20.0

390

2.0

900

-13.0

1410

-20.5

420

1.0

930

-13.5

1440

-20.5

450

0.0

960

-14.0

1470

-21.0

480

-1.5

990

-15.0

 

 

 

Observations: The test item did not change during cooling.

Result: Freezing temperature: <-20 °C (<253 K)

Overall Result: Freezing temperature: <-20 °C (<253 K)

 

Conclusion

The freezing point of the test item has been determined to be less than -20 °C (<253 K).

Description of key information

Freezing temperature: <-20 °C, at 1013 hPa (OECD 102, crystallizing point method)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-20 °C

Additional information