Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vitro, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other: QSAR
Title:
Derek Nexus 6.0
Year:
2017
Bibliographic source:
Derek Nexus is an expert knowledge-based software.

Materials and methods

Principles of method if other than guideline:
- Software tool(s) used including version: Derek Nexus 6.0
- Model(s) used: or Windows - Mutagenicity
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'Cross-reference'
GLP compliance:
no

Test material

1
Chemical structure
Reference substance name:
α-[2-(methylamino)ethyl]benzyl alcohol
EC Number:
255-679-8
EC Name:
α-[2-(methylamino)ethyl]benzyl alcohol
Cas Number:
42142-52-9
Molecular formula:
C10H15NO
IUPAC Name:
3-(methylamino)-1-phenylpropan-1-ol

Results and discussion

Test results
Genotoxicity:
negative
Remarks on result:
other: prediction

Applicant's summary and conclusion

Conclusions:
3-(Methylamino)-1-phenylpropan-1-ol does not satisfy the CLP criteria for mutagenicity classification.
The substance falls within the applicability domain described above and therefore, the predicted value can be considered reliable.