Registration Dossier
Registration Dossier
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EC number: 284-903-7 | CAS number: 84989-14-0
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- expert statement
- Type of information:
- other: assessment of available information
- Executive summary:
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400347), but data are currently available fromin vivoandin vitrotoxicology studies.
The substance, WS400347, is a UVCB substance, calcium salts ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs. The substance has low water solubility (172 mg/l) but it dissociates in water to a sufficient extent to exhibit surface activity. Themolecular weight of the acids amounts to approx. 340 Da (C12 alkyl-derivative). Based on the fact that the substance has surface activity there is no true value for lipophilicity.
It is expected (and was confirmed in bridging studies) that the salt dissociates in aqueous environments. Accordingly, exposure of man and the environment will be to calcium andbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
Calcium is a major element in our daily diet und thus of low toxicity. Therefore, any adverse effects of WS400347 will be based on toxic properties ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
After oral exposure to WS400347 absorption ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivsand systemic distribution is to be expected based on the low molecular weight. In repeat dose feeding studies performed with sodium salts of different linear alkylbenzenesulfonic acids,that were used as read-across source substance, some effects in liver and kidneys were observed at high doses indicating systemic distribution. In acute oral toxicity studies performed in rats with the read-across source substances the LD50 ranged from doses of approx. 1000 to 1600 mg/kg body weight.
Systemic availability of WS400347 after dermal application is expected to be low based on absence of acute dermal toxicity in a study performed with a read-across source substance. However, based on surface activity of WS400347 and based on skin irritation observed with sodium salts of linear alkylbenzenesulfonic acids skin penetration may be enhanced after irritation.
Availability of WS400347 under a vapour state can be excluded, because of its very low vapour pressure (10^-17 Pa, calculated).
There is no information on metabolism and excretion of WS400347.
Based on the available information the bioaccumulation of WS400347 cannot be assessed.
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
Additional information
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400347), but data are currently available fromin vivoandin vitrotoxicology studies.
The substance, WS400347, is a UVCB substance, calcium salts ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs. The substance has low water solubility (172 mg/l) but it dissociates in water to a sufficient extent to exhibit surface activity. Themolecular weight of the acids amounts to approx. 340 Da (C12 alkyl-derivative). Based on the fact that the substance has surface activity there is no true value for lipophilicity.
It is expected (and was confirmed in bridging studies) that the salt dissociates in aqueous environments. Accordingly, exposure of man and the environment will be to calcium andbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
Calcium is a major element in our daily diet und thus of low toxicity. Therefore, any adverse effects of WS400347 will be based on toxic properties ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
After oral exposure to WS400347 absorption ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivsand systemic distribution is to be expected based on the low molecular weight. In repeat dose feeding studies performed with sodium salts of different linear alkylbenzenesulfonic acids,that were used as read-across source substance, some effects in liver and kidneys were observed at high doses indicating systemic distribution. In acute oral toxicity studies performed in rats with the read-across source substances the LD50 ranged from doses of approx. 1000 to 1600 mg/kg body weight.
Systemic availability of WS400347 after dermal application is expected to be low based on absence of acute dermal toxicity in a study performed with a read-across source substance. However, based on surface activity of WS400347 and based on skin irritation observed with sodium salts of linear alkylbenzenesulfonic acids skin penetration may be enhanced after irritation.
Availability of WS400347 under a vapour state can be excluded, because of its very low vapour pressure (10^-17 Pa, calculated).
There is no information on metabolism and excretion of WS400347.
Based on the available information the bioaccumulation of WS400347 cannot be assessed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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