Registration Dossier
Registration Dossier
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EC number: 418-900-0 | CAS number: 42558-54-3 IBEM; MIBA
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: OECD Toolbox v3.4 study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- See attached OECD Toolbox v3.4 full study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl 4-methyl-3-oxopentanoate
- EC Number:
- 418-900-0
- EC Name:
- Methyl 4-methyl-3-oxopentanoate
- Cas Number:
- 42558-54-3
- Molecular formula:
- C7H12O3
- IUPAC Name:
- methyl 4-methyl-3-oxopentanoate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Score:
- 26.1
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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