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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

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Endpoint:
adult fish: sub(lethal) effects
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The substance falls within the applicability domain of the selected (Q)SAR method.
Qualifier:
according to guideline
Guideline:
other: EPI SUITE ECOSAR v 1.0 and 1.11
GLP compliance:
no
Test organisms (species):
other: freshwater fish (unspecified species)
Test type:
other: Chronic 30 d QSAR
Water media type:
freshwater
Total exposure duration:
30 d
Key result
Duration:
30 d
Dose descriptor:
other: ChV (chronic value)
Effect conc.:
0.563 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: not specified in the QSAR
Key result
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
0.398 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: not specified in the QSAR
Details on results:
The estimated toxicity to a freshwater fish species using the US EPA ECOSAR model was 0.563 mg/L (ChV). According to ECHA REACH Guidance R.10, if in the test report only the ChV is presented, this value can be divided by √2 to derive a NOEC. 0.563 mg/L was divided by root 2 to give a NOEC value of 0.398 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Under the study conditions, 30 d NOEC for freshwater fish was considered to be 0.398 mg/L.
Executive summary:

A study was conducted to determine the chronic toxicity of the test substance to freshwater fish using the EPI SUITE ECOSAR v 1.0 and 1.11 model. The estimated 30 d ChV (chronic value) was 0.563 mg/L. The ChV corresponds to the geometric mean of the NOEC and LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be divided by √2 to derive a NOEC. In this case 0.563 mg/L was divided by root 2 to yield a NOEC value of 0.398 mg/L. Under the study conditions, 30 d NOEC for freshwater fish was therefore considered to be 0.398 mg/L (US EPA, 2017).

Endpoint:
adult fish: sub(lethal) effects
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The substance falls within the applicability domain of the selected (Q)SAR method.
Qualifier:
according to guideline
Guideline:
other: EPI SUITE ECOSAR v 1.0 and 1.11
GLP compliance:
no
Test organisms (species):
other: Saltwater fish (species unspecified)
Test type:
other: chronic toxicity study (assume 30 d)
Water media type:
saltwater
Total exposure duration:
30 d
Key result
Duration:
30 d
Dose descriptor:
other: ChV
Effect conc.:
1.636 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
other: QSAR
Key result
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
1.16 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Details on results:
The estimated toxicity to a salt water fish species using the EPA ECOSAR model is 1.636 mg/L (ChV). According to ECHA REACH Guidance R.10, if in the test report only the ChV is presented, the ChV can be divided by √2 to derive a NOEC. 1.636 mg/L was divided by root 2 to give a NOEC value of 1.160 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Under the study conditions, the 30 d NOEC for marine fish was considered to be 1.160 mg/L.
Executive summary:

A study was conducted to determine the chronic toxicity of the test substance to marine fish using the EPI SUITE ECOSAR v 1.0 and 1.11 model. The ChV corresponds to the geometric mean of the NOEC and LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be divided by √2 to derive a NOEC. In this case 1.636 mg/L was divided by root 2 to give a NOEC value of 1.160 mg/L. Under the study conditions, the 30 d NOEC for marine fish was therefore considered to be 1.160 mg/L (US EPA, 2017).

Description of key information

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.398 mg/L

Marine water fish

Marine water fish
Effect concentration:
1.16 mg/L

Additional information

Freshwater fish

A study was conducted to determine the chronic toxicity of the test substance to freshwater fish using the EPI SUITE ECOSAR v 1.0 and 1.11 model. The estimated 30 d ChV (chronic value) was 0.563 mg/L. The ChV corresponds to the geometric mean of the NOEC and LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be divided by √2 to derive a NOEC. In this case 0.563 mg/L was divided by root 2 to yield a NOEC value of 0.398 mg/L. Under the study conditions, 30 d NOEC for freshwater fish was therefore considered to be 0.398 mg/L (US EPA, 2017).

Marine fish

A study was conducted to determine the chronic toxicity of the test substance to marine fish using the EPI SUITE ECOSAR v 1.0 and 1.11 model. The ChV corresponds to the geometric mean of the NOEC and LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be divided by √2 to derive a NOEC. In this case 1.636 mg/L was divided by root 2 to give a NOEC value of 1.160 mg/L. Under the study conditions, the 30 d NOEC for marine fish was therefore considered to be 1.160 mg/L (US EPA, 2017).