Registration Dossier
Registration Dossier
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EC number: 236-631-5 | CAS number: 13453-69-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- At physiological pH, all lithium borates dissociate and release boric acid and lithium ions as a result of relevant transformation pathways. It will the boric acid component of the substances which will drive the mammalian toxicity endpoints. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in skin irritation. In order to minimise animal testing, only one substance in the category was tested, dilithium tetraborate. For all other substances in the category, read-across is proposed.
Data source
Materials and methods
Test material
- Reference substance name:
- Lithium metaborate
- EC Number:
- 236-631-5
- EC Name:
- Lithium metaborate
- Cas Number:
- 13453-69-5
- Molecular formula:
- BHO2.Li
- IUPAC Name:
- lithium metaborate
Constituent 1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, an in vitro skin irritation test was conducted according to OECD 439. Dilithium tetraborate was found to be non-irritant and should not be classified according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations. Lithium metaborate is also expected to be non-irritant.
- Executive summary:
An in vitro skin irritation test was conducted according to OECD 439. Dilithium tetraborate was found to be non-irritant. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity as at physiological pH, all the substances dissociate to provide the same common compounds. All substances in the category do not meet CLP criteria for classification as skin irritants.
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