Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-946-9 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 September 1965 to 16 December 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Regulations (Federal Register, August 12, 1961 et seq) under the Federal Hazardous Substances Labeling Act
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Molybdenum, bis[O,O-bis(2-ethylhexyl) phosphorodithioato-.kappa.S,.kappa.S']dioxodi-.mu.-thioxodi-, (Mo-Mo)
- EC Number:
- 615-708-0
- Cas Number:
- 72030-25-2
- Molecular formula:
- N/A
- IUPAC Name:
- Molybdenum, bis[O,O-bis(2-ethylhexyl) phosphorodithioato-.kappa.S,.kappa.S']dioxodi-.mu.-thioxodi-, (Mo-Mo)
- Reference substance name:
- Molybdenum, bis[O,O-bis(2-ethylhexyl) phosphorodithioato-.kappa.S,.kappa.S']-.mu.-oxodioxo-.mu.-thioxodi-
- Cas Number:
- 153128-45-1
- Molecular formula:
- N/A
- IUPAC Name:
- Molybdenum, bis[O,O-bis(2-ethylhexyl) phosphorodithioato-.kappa.S,.kappa.S']-.mu.-oxodioxo-.mu.-thioxodi-
- Reference substance name:
- Molybdenum, bis[O,O-bis(2-ethylhexyl) phosphorodithioato-.kappa.S,.kappa.S']oxodi-.mu.-thioxothioxodi-
- Molecular formula:
- N/A
- IUPAC Name:
- Molybdenum, bis[O,O-bis(2-ethylhexyl) phosphorodithioato-.kappa.S,.kappa.S']oxodi-.mu.-thioxothioxodi-
- Reference substance name:
- Unspecified 2-ethylhexyl thiophosphate esters
- Molecular formula:
- N/A
- IUPAC Name:
- Unspecified 2-ethylhexyl thiophosphate esters
- Reference substance name:
- Unspecified 2-ethylhexyl phosphate esters
- Molecular formula:
- N/A
- IUPAC Name:
- Unspecified 2-ethylhexyl phosphate esters
- Reference substance name:
- Unspecified 2-ethylhexyl dithiophosphate esters
- Molecular formula:
- N/A
- IUPAC Name:
- Unspecified 2-ethylhexyl dithiophosphate esters
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Test animals
- Species:
- rat
- Strain:
- other: Holtzman
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 270-281 grams
- Fasting period before study: Yes. 18 hours before prior to dosage.
- Housing: Wire mesh cages in groups.
- Diet (e.g. ad libitum): food consisting of commercial pellets ad libitum.
- Water (e.g. ad libitum): Water available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 0.464, 1.00, 2.15, 4.64, 10.0 and 21.5 ml/kg of body weight
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed closely day of dosage and at least once daily there after.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight. - Statistics:
- Statistical analysis of the mortality data was by the moving average method (Weil, C.S., Biometrics 8, 249, 1952)
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6.81 mL/kg bw
- Based on:
- test mat.
- Mortality:
- Deaths were noted after 24 hours of doses 10.0 and 21.5 ml/kg.
- Clinical signs:
- other: Signs noted included depression, mucoid diarrhea with greenish stools. Depressed or absent righting and placement reflexes were observed in these animals which died during the night following the dosage.
- Gross pathology:
- Findings in animals that died included congested lungs and kidneys; stomach filled with green fluid; and small and large intestines distended with green fluid and gas. Gross autopsies performed on the surviving rats at termination showed no significant gross pathological changes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 for male abino rats was found to be 6.81 ml/kg of body weight. The acute toxicity was evaluated using the procedures outlined in the Regulations under the Federal Hazardous Substances Labeling Act.
- Executive summary:
The acute oral LD50 for male abino rats was found to be 6.81 ml/kg of body weight. The acute toxicity was evaluated using the procedures outlined in the Regulations under the Federal Hazardous Substances Labeling Act.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
