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EC number: 942-445-1
CAS number: -
The percutaneous absorption and cutaneous disposition of topically
applied neat Jet-A, JP-8, and JP-8(100) jet fuels (25 uL/5 cm2) was
examined by monitoring the absorptive flux of the marker components 14C
naphthalene and 4H dodecane simultaneously applied non-occluded to
isolated perfused porcine skin flaps (a = 4). Absorption of 14C
hexadecane was estimated from JP-8 fuel. Absorption and disposition of
naphthalene and dodecane were also monitored using a nonvolatile JP-8
fraction reflecting exposure to residual fuel that might occur 24 h
after a jet fuel spill. In all studies, perfusate, stratum corneum, and
skin concentrations were measured over 5 h. Naphthalene absorption had a
clear peak absorptive flux at less than 1 h, while dodecane and
hexadecane had prolonged, albeit significantly lower, absorption flux
profiles. Within JP-8, the rank order of absorption for all marker
components was (mean +/- SEM; % dose) naphthalene (1.17 +/- 0.07) >
dodecane (0.63 +/- 0.04) > hexadecane (0.18 +/- 0.08). The area under
the curve (AUC) was determined to be (mean +/- SEM; % dose-h/mL):
naphthalene (0.0199 +/- 0.0020) > dodecane (0.0107 +/- 0.0009) >
hexadecane (0.0017 +/- 0.0003). In contrast, deposition within dosed
skin showed the reverse pattern.
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