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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 June to 14 June, 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: done under GLP and OECD method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
430-900-2
EC Name:
-
Cas Number:
192725-50-1
Molecular formula:
Hill formula: C9H16N2O3 CAS formula: C9H16N2O3
IUPAC Name:
3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanoic acid

Results and discussion

Water solubilityopen allclose all
Water solubility:
16.197 g/L
Temp.:
21 °C
pH:
2.6
Remarks on result:
other: at 3 hrs
Water solubility:
15.429 g/L
Temp.:
21 °C
pH:
2.63
Remarks on result:
other: at 6 hrs
Water solubility:
15.801 g/L
Temp.:
21 °C
pH:
2.58
Remarks on result:
other: at 24 hrs
Water solubility:
15.377 g/L
Temp.:
21 °C
pH:
2.55
Remarks on result:
other: at 30 hrs
Water solubility:
15.641 g/L
Temp.:
21 °C
pH:
2.61
Remarks on result:
other: at 48 hrs
Details on results:
The water solubility determined by the flask stirring method at the temperature of 21ºC is: 
15.685 ± 3.86 g/l
n=11, CV= 2.461%

Any other information on results incl. tables

The pH at the saturation concentration ranged from 2.55 to 2.63

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L) 15.685 ± 3.86 g/l
The water solubility of A-164220.0 was evaluated to be 15.685 ± 3.86 g/l (n=11) @ 21°C
Executive summary:

Equilibrium saturation occured verey quickly. At the 3 hr sampling time the saturation value found did not differ significantly from the values recorded at the successive times.

It was also observed that prolonged stirring did not increase the saturation equilibrium and that the test substance did not decompose on staying longer in water.