Registration Dossier
Registration Dossier
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EC number: 424-660-8 | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 July – 03 October, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OJEC L383 A/54-62
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Paris 1981
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- -
- EC Number:
- 424-660-8
- EC Name:
- -
- Cas Number:
- 224631-15-6
- Molecular formula:
- Hill formula: C18H26N4O5S CAS formula: C18H26N4O5S
- IUPAC Name:
- 2,5-dioxopyrrolidin-1-yl (2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanoate
Constituent 1
Results and discussion
Water solubility
- Remarks on result:
- other: In water, A-133816.0 hydrolyses nearly completely such that its aqueous solubility could not be determined.
- Details on results:
- In water, A-133816.0 hydrolyses nearly completely to 2,4 wing acid (A-87681.0) such that its aqueous solubility could not be determined.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Hydrolyes almost completely
In water, A-133816.0 hydrolyses nearly completely such that its aqueous solubility could not be determined. - Executive summary:
During the shake flask testing it was noted - on visual
inspection of the test samples - that the excess material
added to ensure saturation of the samples appeared to have
dissolved. Analysis of the test samples for A-133816
demonstrated that no test material was present in the
solutions. The samples were also analyed for 2,4-Wing Acid,
a known hydrolysis product of A-133816. Quantification of
the 2,4-Wing Acid accounted for most of the theoretical
quantity of A-133816 having undergone hydrolysis (ca96%
hydrolysis).
96% of substance hydrolyzes. The water solubility is not
detectable due to the substance completely dissolved.
Also tested for its hydrolysis product 2,4-Wing Acid
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