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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 February 2016 - 23 February 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
Lot number 141016
Purity ≥85.5%
Description Blue Powder
Key result
Percentile:
D10
Mean:
< 18.116 µm
St. dev.:
0.31
Key result
Percentile:
D50
Mean:
< 219.732 µm
St. dev.:
3.775
Key result
Percentile:
D90
Mean:
< 550.361 µm
St. dev.:
11.945
Conclusions:
Volume weighted mean: 254.209 μm
Median (d.50): 219.732 μm
Mode: 391.596 μm
10 % of material is < 18.116 μm
50 % of material is < 219.732 μm
90 % of material is < 550.361 μm
by volume of sample was seen to be < 10.00 μm: 6.02%

Description of key information

10 % of material is < 18.116 μm

50 % of material is < 219.732 μm

90 % of material is < 550.361 μm

by volume of sample was seen to be < 10.00 μm: 6.02%

Additional information

A determination of the particle size distribution of B331 was conducted (CiToxLAB Hungary, 2017, Study 15/361-386AN). The determination was conducted initially by microscopic inspection (100x and 400x magnification) then by laser diffraction. The laser diffraction analysis was condcuted in accordance with OECD method 110 and ISO13320:2009. The study was conducted in compliance with GLP.

The median particle size was found to be 219.732µm. 6.02% of the sample was found to be less than 10µm.