Registration Dossier
Registration Dossier
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EC number: 948-046-9 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 September 2017 to ****
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: slow stir method, based on OECD 123
- Specific details on test material used for the study:
- Physical state: Dark amber liquid
Purity: >93 % - Key result
- Water solubility:
- < 0 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: result the same for pH 7 and 9, also.
- Remarks:
- High molecular weight component
- Key result
- Water solubility:
- 0 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other:
- Remarks:
- Low molecular weight component
- Key result
- Water solubility:
- 0.001 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other:
- Remarks:
- Low molecular weight component
- Key result
- Water solubility:
- 0 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 9
- Remarks on result:
- other:
- Remarks:
- Low molecular weight component
- Conclusions:
- The aqueous solubility of the test item at each pH has been determined to be <0.00027 µg/mL at 20 °C.
- Executive summary:
In a study performed to the standardised guideline OECD 105, under GLP conditions, the aqueous solubility of the test item at each pH has been determined to be <0.00027 µg/mL at 20 °C, Smithers Viscient (ESG) Ltd. (2018).
Reference
The high molecular weight component gave results that were near the limit of quantification (0.00027 µg/mL). At pH 5 it was 0.000048 µg/mL, at pH 7 it was 0.000075 µg/mL and at pH 9 it was 0.00009 µg/mL (mean of the last five results). An attempt to validate at these levels was considered unfeasible as the expected concentrations would be at the limit of detection. Therefore it should be considered that the aqueous solubility at each pH was <0.00027 µg/mL.
Description of key information
In a study performed to the standardised guideline OECD 105, under GLP conditions, the aqueous solubility of the test item at each pH has been determined to be <0.00027 µg/mL at 20 °C, Smithers Viscient (ESG) Ltd. (2018).
Key value for chemical safety assessment
- Water solubility:
- 0 µg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
