1-Propanaminium, 2-hydroxy-N-(2-hydroxyethyl)-N-methyl-N-[2-[(1-oxo-9-octadecen-1-yl)amino]ethyl]-3-sulfo-, methyl sulfate, sodium salt (1:1:1)

Oxidising properties

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

oxidising liquids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-10-17 to 2018-11-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test O.2 (Test for oxidizing liquids)

Version / remarks:

2015

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Contact with:

powdered cellulose

Duration of test (contact time):

60 s

Key result

Sample tested:

reference mixture with 50% perchloric acid + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

1 642 other: kPa

Key result

Sample tested:

reference mixture with 40% aqueous sodium chlorate + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

1 826 other: kPa

Key result

Sample tested:

reference mixture with 65% nitric acid + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

1 650 other: kPa

Key result

Sample tested:

test mixture 1:1

Parameter:

mean pressure rise time

Result:

1 701 other: kPa

Remarks on result:

maximum pressure of 2070 kPa not reached

Results and Interpretation

The test was performed with the comparison of 1:1 mixtures of test item with cellulose and reference substance (50% perchloric acid, 40% aq. sodium chlorate and 65 % nitric acid) with cellulose.

For the 1:1 ratio of test item and cellulose mixture a mean pressure rose of less than 2070 kPa was observed. Thus, the test item has no oxidizing properties and does not need to be classified as oxidizing liquid in Division 5.1.

The 1:1 ratio of reference substance (50% perchloric acid, 40% aq. sodium chlorate and 65% nitric acid) and cellulose mixture pressure rose and bursting disk ruptured within a minute.

Table 1: Oxidising properties of reference mixture (50% w/w perchloric acid and cellulose)

Name of Substance	Replication No.	Time Taken for Pressure Rose (Sec)	Pressure Rose (Bar)	Pressure Rose (kPa)	Observation
Reference substance (50% w/w Perchloric acid: Cellulose)	R1	1	15.43	1543	Bursting disk was ruptured within a minute
	R2	1	16.53	1653
	R3	1	18.18	1818
	R4	1	16.12	1612
	R5	1	15.83	1583
Mean ± SD & (%) RSD	-	1±0.0 & 0.0	-	1642±106.39 & 6.48

Table 2: Oxidising properties of reference mixture (40% w/w sodium chlorate and cellulose)

Name of Substance	Replication No.	Time Taken for Pressure Rose (Sec)	Pressure Rose (Bar)	Pressure Rose (kPa)	Observation
Reference substance (40% w/w sodium chlorate: cellulose)	R1	2	18.16	1816	Bursting disk was ruptured within a minute
	R2	2	19.11	1911
	R3	2	18.75	1875
	R4	2	17.81	1781
	R5	2	17.47	1747
Mean ± SD & (%) RSD	-	2±0.0 & 0.0	-	1826±67.07 & 3.67

Table 3: Oxidising properties of reference mixture (65% w/w Nitric acid and cellulose)

Name of Substance	Replication No.	Time Taken for Pressure Rose (Sec)	Pressure Rose (Bar)	Pressure Rose (kPa)	Observation
Reference substance (65% w/w Nitric acid: Cellulose)	R1	4	15.98	1598	Bursting disk was ruptured within a minute
	R2	4	16.73	1673
	R3	4	16.59	1659
	R4	4	16.25	1625
	R5	4	19.93	1693
Mean ± SD & (%) RSD	-	4±0.45 & 10.71	-	1650±38.04 & 2.31

Table 4: Oxidising properties of test item mixture

Name of Substance	Replication No.	Time Taken for Pressure Rose (Sec)	Pressure Rose (Bar)	Pressure Rose (kPa)	Observation
Test substance (Test item & Cellulose)	R1	60	16.94	1694	Bursting disk was not ruptured within a minute
	R2	60	16.73	1673
	R3	60	17.02	1702
	R4	60	16.98	1698
	R5	60	17.36	1736
Mean ± SD & (%) RSD	-	60±0.0 & 0.0	-	1701±22.73 & 1.34

kPa = 1 Bar x 10²

Interpretation of results:

GHS criteria not met

Conclusions:

The test item has no oxidizing properties.

Executive summary:

The oxidising properties of the test item was determined in accordance with test method of Part III sub-section 34.4.2 Test O.2.: Test for oxidising liquids of the UN Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, sixth revised edition, 2015. The oxidizing properties test was performed with the comparison of 1:1 mixture of test item and cellulose with reference substance (50% perchloric acid, 40% aq. sodium chlorate and 65 % nitric acid) and cellulose. For the 1:1 ratio of test item and cellulose mixture a mean pressure rose of 1701 ± 22.73 kPa was observed. Thus, the test item has no oxidizing properties and does not need to be classified as oxidizing liquid in Division 5.1.

Reference 2

Endpoint:

oxidising gases

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Reference 3

Endpoint:

oxidising solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

According to the guideline O.1 (Test for oxidizing solids), the test item is to be dried at 105 °C and the dried material is supposed to be used subsequently for the test. The testing laboratory started the oxidizing solids with the test item but during the trial on heating at 205 °C for about 2 hours, the test item (paste substance) was found to be viscous liquid. Hence, the test item is not suitable to carry out the oxidizing properties of solids (O.1) and the test for oxidizing liquids (O.2) was performed.

Description of key information

The test item has no oxidizing properties.

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Additional information

Oxidising liquids

The oxidising properties of the test item was determined in accordance with test method of Part III sub-section 34.4.2 Test O.2.: Test for oxidising liquids of the UN Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, sixth revised edition, 2015. The oxidizing properties test was performed with the comparison of 1:1 mixture of test item and cellulose with reference substance (50% perchloric acid, 40% aq. sodium chlorate and 65 % nitric acid) and cellulose. For the 1:1 ratio of test item and cellulose mixture a mean pressure rose of 1701 ± 22.73 kPa was observed. Thus, the test item has no oxidizing properties and does not need to be classified as oxidizing liquid in Division 5.1.

Oxidising gases

The test item is a solid at ambient conditions. This hazard class is only applicable for gases. Thus, the substance was not considered for classification as oxidising gases.

Oxidising solids

The study does not need to be conducted because the substance is a liquid. According to the guideline O.1 (Test for oxidizing solids), the test item is to be dried at 105 °C and the dried material is supposed to be used subsequently for the test. The testing laboratory started the oxidizing solids with the test item but during the trial on heating at 205 °C for about 2 hours, the test item (paste substance) was found to be viscous liquid. Hence, the test item is not suitable to carry out the oxidizing properties of solids (O.1) and the test for oxidizing liquids (O.2) was performed.

Justification for classification or non-classification

Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008

The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on the available data, the test item is not classified according to Regulation (EC) No 1272/2008 (CLP), as amended for the twelfth time in Regulation (EU) No 2019/521.