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Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-12-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
31.6 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
10.22

Preliminary Test:

Approximate solubility was above 10 mg/L.

Main Test:

Results of the water solubility of test item: 

Time of

shaking

[h]

Analyte concentration

Flask 1

Analyte concentration

Flask 2

mean concentration

[g/L]

pH value

2

32.5

30.5

31.5

10.20

4

32.4

30.7

31.6

10.21

6

32.3

31.1

31.7

10.24

 

Mean:

31.6

10.22

Standard deviation:

0.9

0.02

Relative standard deviation[%):

2.8

0.2

The results indicate the required reproducibility (relative standard deviation below 15 %) and no tendency to increasing values, when the shaking time was prolonged.

Conclusions:
The water solubility of the test item in ultra-pure water saturated with carbon dioxide at 20 ± 0.5°C was determined to be 31.6 g/L (pH 10.22).
Executive summary:

The solubility of test item was determined in ultra-pure water in equilibrium with atmospheric carbon dioxide at a temperature of 20±0.5 °C according to EC method A.6 (Regulation (EC) No 440/2008) and OECD guideline 105. The shake flask method was used, because the solubility determined in the preliminary test was above 10 mg/L.

The water solubility of the test item was determined to be 31.6 g/L (pH 10.22). The results indicate the required reproducibility (relative standard deviation below 15 %) and no tendency to increasing values, when the shaking time was prolonged.

Description of key information

The solubility of test item was determined in ultra-pure water in equilibrium with atmospheric carbon dioxide at a temperature of 20±0.5 °C according to EC method A.6 (Regulation (EC) No 440/2008) and OECD guideline 105. The shake flask method was used, because the solubility determined in the preliminary test was above 10 mg/L.

The water solubility of the test item was determined to be 31.6 g/L (pH 10.22).

Key value for chemical safety assessment

Water solubility:
31.6 g/L
at the temperature of:
20 °C

Additional information