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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 February 2018 to 28 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Remarks:
slow stirring
Key result
Water solubility:
0.42 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
10 other: µL
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
7.5
Details on results:
PRELIMINARY TEST
- Based on a visual observation it was concluded that water solubility of the test item is < 1000 g/L.
- In the second preliminary test, the content of test item dissolved in the water sample was < 0.00163 g/L.

MAIN STUDY
- The results for the samples taken at 24, 48 and 72 hours are given in Table 6 (below).
- The 24-hour measurement was higher than the 48- and 72-hour measurements (maximum difference > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements.
- No test item was detected in the pre-treated sample from the blank water mixture.

TABLE 6 – SOLUBILITY OF THE TEST ITEM IN THE MAIN STUDY

Stirring time (h)

Analysed concentration (mg/L)*

pH

24

0.513

7.5

48

0.414

7.5

72

0.425

7.5

* Mean value = 0.420 mg/L (maximum difference 2.6 %)

Conclusions:
Water solubility was determined by the slow-stirring flask method to be 0.420 mg/L at 20°C and pH 7.5.
Executive summary:

GUIDELINE

The investigation was conducted in accordance with OECD Guideline 105 Water Solubility (July 27, 1995) and EC Guideline A.6 Water Solubility (March 04, 2016) and OPPTS 830.7840.

 

RESULTS

Water solubility was determined by the slow-stirring flask method to be 0.420 mg/L at 20°C and pH 7.5.

Description of key information

Water solubility was determined by the slow-stirring flask method to be 0.420 mg/L at 20 °C and pH 7.5 (OECD 105, EU Method A.6 and OPPTS 830.7840).

Key value for chemical safety assessment

Water solubility:
0.42 mg/L
at the temperature of:
20 °C

Additional information

GUIDELINE

The investigation was conducted in accordance withOECD Guideline 105 Water Solubility (July 27, 1995) and EC Guideline A.6 Water Solubility (March 04, 2016) and OPPTS 830.7840.

 

RESULTS

Water solubility was determined by the slow-stirring flask method to be 0.420 mg/L at 20 °C and pH 7.5.