Esterification products of salicylic acid and C13-(branched) alcohols

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22/11/2017 to 30/4/2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27 July 1995

Deviations:

no

Principles of method if other than guideline:

See attached method validation.

GLP compliance:

yes (incl. QA statement)

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

tridecyl 2-hydroxybenzoate

EC Number:

947-975-7

Molecular formula:

C20H32O3

IUPAC Name:

tridecyl 2-hydroxybenzoate

Specific details on test material used for the study:

Test Item
Identification: Dermol TDSA
Appearance: Colourless to pale yellow clear liquid
Batch: P7202
Purity/Composition: UVCB
Test item storage: At room temperature
Stable under storage conditions until: 11 November 2021 (expiry date)

Additional information
Test Facility test item number: 209078/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Molecular structure: Not indicated
Molecular formula: C20H32O3
Molecular weight: 320

Test Item Characterization
The Sponsor provided to the Test Facility documentation of the identity, purity, composition, and stability for the test item(s). A Certificate of Analysis or equivalent document was provided to the Test Facility and is presented in Appendix 2.

Results and discussion

Water solubility

Water solubility 1

Key result

Water solubility:

< 0 mg/L

Conc. based on:

test mat.

Incubation duration:

ca. 72 h

Temp.:

20 °C

pH:

ca. 7.7

Water solubility 2

Key result

Water solubility:

< 0 mg/L

Conc. based on:

test mat.

Incubation duration:

ca. 72 h

Temp.:

20 °C

pH:

ca. 7.8

Details on results:

See "Other information"

Any other information on results incl. tables

Results                   

A very small response at the retention time of the test item was detected in the chromatogram of the test sample. This response was significantly below the response of the lowest calibration concentration of 0.76 mg/L

Main study           

The results for the samples taken at 24, 48 and 72 hours are given inTable 6andTable 7for the low and high loading rate respectively.

No test item was detected at either loading rates. The water solubility is therefore reported as lower than the limit of detection (LOD). The LOD was determined to be 0.000039 mg/L, this corresponds with 0.000078 mg/L when taking a dilution factor of 2 into account.

Since no test item was detected in the test samples, undissolved test item was sampled from a high loading rate water phase, diluted and analysed. A peak was observed at the retention time of the test item

No test item was detected in the pretreated sample from the blank water mixture.

Table 6          
Main study - water solubility of the test item at a low loading rate

Stirring time [hours]	Analyzed concentration [mg/L]	Mean [mg/L]	Maximum difference [%]	pH
24	< 0.000078	< 0.000078	n.a.	7.7
48	< 0.000078			7.8
72	< 0.000078			7.8

 

Table 7          
Main study - water solubility of the test item at a high loading rate

Stirring time [hours]	Analyzed concentration [mg/L]	Mean [mg/L]	Maximum difference [%]	pH
24	< 0.000078	< 0.000078	n.a.	7.7
48	< 0.000078			7.6
72	< 0.000078			7.7

 

Applicant's summary and conclusion

Conclusions:

The water solubility of the test substance was found to be < 0.000078 mg/l at high and low loading rates at 20 °C, under the conditions of the test.

Executive summary:

In this guideline (OECD 105) study, [conducted with GLP certification], the water solubility of the test substance was found to be < 0.000078 mg/l at high and low loading rates at 20 °C.