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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes

Test material

Test material form:
solid
Specific details on test material used for the study:
Purity ca. 97 %; Meltingpoint: 145 - 151°C

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: HOECHST AG, SPF-Zucht
- Weight at study initiation: 171 g - 189 g (average 180 g)
- Fasting period before study: 16 hours
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesam oil
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5

Results and discussion

Mortality:
No mortalities were observed. (Observation time post application: 14 days)
Clinical signs:
No clinical signs were reported.
Body weight:
No effect to the body weight gain was observed. (Observation time post application: 14 days)
Gross pathology:
No gross pathological changes were observed after necropsy.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of the test item was found to be > 5,000 mg/kg bw.

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