Registration Dossier
Registration Dossier
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EC number: 206-075-8 | CAS number: 299-28-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- RCC Umweltchemie AG
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Name: 28723 - Ca-Gluconate
- Aggregate state at room temperature: solid
- Colour: white
- Expiry Date: March 27, 2018
- Storage conditions at test facility: at 20 °C ± 5 °C, in the dark - Analytical method:
- liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -0.38
- Temp.:
- 21 °C
- Remarks on result:
- other: No data on pH value
- Type:
- Pow
- Partition coefficient:
- 0.421
- Temp.:
- 21 °C
- Remarks on result:
- other: No data on pH value
- Conclusions:
- The logarithmic partition coefficient (n-octanol/water) log Pow of the test item was determined to be < - 5.31 at 20°C
- Executive summary:
The purpose of the study was to determine the partition coefficient of the test item between n-octanol and water using the shake flask method. This study was conducted in accordance with OECD test method no. 107. The partition coefficient was calculated based on the results of the analytical determination. The test item content was determined by LC-MS/MS. Due to the very low solubility of the test item in octanol, the concentration could not be determined. The log Pow was calculated with the Limit of Detection (LOD). The LOD was determined to be 0.02 mg/l. The logarithmic partition coefficient (n-octanol/water) log Pow of the test item was determined to be < - 5.31 at 20°C
Reference
Description of key information
The purpose of the study was to determine the partition coefficient of the test item between n-octanol and water using the shake flask method. This study was conducted in accordance with OECD test method no. 107. The partition coefficient was calculated based on the results of the analytical determination. The test item content was determined by LC-MS/MS. Due to the very low solubility of the test item in octanol, the concentration could not be determined. The log Pow was calculated with the Limit of Detection (LOD). The LOD was determined to be 0.02 mg/l. The logarithmic partition coefficient (n-octanol/water) log Pow of the test item was determined to be < - 5.31 at 20°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -5.31
- at the temperature of:
- 20 °C
Additional information
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