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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Principles of method if other than guideline:
An excess of product is shaked with solvent during 24 hours at 20 deg C. The concentration in solution is determined visually.
GLP compliance:
not specified
Type of method:
other: no data
Water solubility:
< 60 g/L
Temp.:
20 °C
pH:
7.8
Conclusions:
The water solubility of T002675 was determined to be below 60 g/L at 20°C and pH= 7.8.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007-08-21 to 2007-11-22
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP study performed according to OECD Guideline 105 (Water Solubility) and EU Method A.6 (Water Solubility). In the pretest , the substance is concluded to be miscible with water based on the visual observation.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The testing facility reported the following deviations from the protocol:1) In the pretest , the substance is concluded to be miscible with water based on the visual observation.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
The testing facility reported the following deviations from the protocol:1) In the pretest , the substance is concluded to be miscible with water based on the visual observation.
GLP compliance:
yes (incl. certificate)
Remarks:
Federal Office of Environment, Water Management and Supervision of Trade
Type of method:
other: pretest only
Specific details on test material used for the study:
- Identity: TIC876 (T002675)
- Batch: 603T-1
- Purity: 97.76%
- Expiration date: December 19, 2007
- Storage: at room temperature (about 20°C)
Water solubility:
> 10 g/L
Remarks on result:
other: No temperature or pH value available
Details on results:
The test substance was miscible with water in all proportions tested.
Conclusions:
The test substance was completely miscible in water in all proportions tested.

Description of key information

A K2 GLP study was performed according to OECD guideline 105 and EU Method A.6 (flask method). The test substance was completely miscible in water in all proportions tested (Paulus, 2007).

Key value for chemical safety assessment

Additional information

Three different ratios of test substance and deonized water were mixed for this test-1mL each component; 5 g test substance, 1 drop water; and 1 drop test substance, 5 g water. Only the pre-test was conducted to determine the water solubility of T002675. Based on visual observations, the substance was determined to be very soluble (>10 g/L) because miscible in all proportions tested.

Another study was performed by J&J PRD. The water solubility of T002675 was determined to be below 60 g/L at 20°C and pH 7.8. As the information was insufficient to determine the reliability of the study a K4 reliability score was assigned to this supporting study.