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EC number: 816-307-5 | CAS number: 45738-97-4
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Jan 20118 - 29 Jan 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- GLP compliance:
- yes
- Other quality assurance:
- other: ISO 13320:2009 “Particle Size Analysis – Laser Diffraction Methods
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- agglomerate
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 3,7-dihydropurin-6-one;sodium
- Cas Number:
- 45738-97-4
- Molecular formula:
- C5H3N4NaO
- IUPAC Name:
- 3,7-dihydropurin-6-one;sodium
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: White powder
- Purity / Composition: 98%
- Test item storage: Room temperature
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- ca. 3.717 µm
- Geometric standard deviation:
- > 1.964 - < 1.991
Particle sizeopen allclose all
- Key result
- Percentile:
- D10
- Mean:
- ca. 1.177 µm
- St. dev.:
- 0.012
- Key result
- Percentile:
- D50
- Mean:
- ca. 2.748 µm
- St. dev.:
- 0.045
- Key result
- Percentile:
- D90
- Mean:
- ca. 6.801 µm
- St. dev.:
- 0.108
Any other information on results incl. tables
Table 8:1 : Full Test Results
Run No. |
RUN 1 |
RUN 2 |
RUN 3 |
RUN 4 |
RUN 5 |
Average** |
Volume weighted mean |
3.556 |
3.512 |
3.497 |
3.437 |
3.418 |
3.484 |
Median |
2.808 |
2.787 |
2.749 |
2.702 |
2.694 |
2.748 |
Mode |
2.708 |
2.695 |
2.625 |
2.568 |
2.569 |
2.631 |
MMAD * |
3.799 |
3.771 |
3.719 |
3.655 |
3.645 |
3.717 |
d10 - 10 % of material is < |
1.193 |
1.189 |
1.175 |
1.166 |
1.165 |
1.177 |
d50 - 50 % of material is < |
2.808 |
2.787 |
2.749 |
2.702 |
2.694 |
2.748 |
d90 - 90 % of material is < |
6.953 |
6.846 |
6.844 |
6.706 |
6.651 |
6.801 |
All results are in µm
* Mass median aerodynamic diameter
** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
97.17 % by volume of sample was seen to be < 10.00 µm
Table 8:2: Standard Deviation results
Run No. |
1 |
2 |
3 |
4 |
5 |
STDVP |
% STDVP |
d10 - 10 % of material is < |
1.193 |
1.189 |
1.175 |
1.166 |
1.165 |
0.012 |
1 |
d50 - 50 % of material is < |
2.808 |
2.787 |
2.749 |
2.702 |
2.694 |
0.045 |
1.6 |
d90 - 90 % of material is < |
6.953 |
6.846 |
6.844 |
6.706 |
6.651 |
0.108 |
1.6 |
d15.78 - 15.78 % of material is < |
1.41 |
1.404 |
1.387 |
1.374 |
1.372 |
0.015 |
1.1 |
GSD |
1.991 |
1.985 |
1.982 |
1.967 |
1.964 |
0.011 |
0.5 |
MMAD |
3.799 |
3.771 |
3.719 |
3.655 |
3.645 |
0.061 |
1.6 |
GSD = Geometric standard deviation of the lognormal particle size distribution (calculated from d50/d15.78) STDVP = standard deviation of the population
% STDVP = percentage standard deviation of the population
Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
Applicant's summary and conclusion
- Conclusions:
- The particle size was analyzed over the range 0.02 µm to 2000 µm using a DPM Module. The average result is calculated from the entirety of data captured in each of the five runs. The averages are: d10 - 10 % of material is <1.177, d50 - 50 % of material is <2.748, and d90 - 90 % of material is <6.801.
- Executive summary:
The particle size was analyzed over the range 0.02 µm to 2000 µm using a DPM Module. The average result is calculated from the entirety of data captured in each of the five runs. The averages are: d10 - 10 % of material is <1.177, d50 - 50 % of material is <2.748, and d90 - 90 % of material is <6.801.
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