Registration Dossier
Registration Dossier
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EC number: 278-031-6 | CAS number: 74931-55-8
Endpoint summary
Administrative data
Description of key information
An assessment was undertaken based on available data on the individual constituents of the substance. A NOAEL of 300 mg/kg bw/d is proposed for the short-term repeated-dose toxicity of 2-ethylhexanoic acid, compound with 2-aminoethanol (1:1) via the oral route. This value is considered as conservative. The substance does not induce specific target organ toxicity.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was undertaken based on available data on the individual constituents of the substance.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was undertaken based on available data on the individual constituents of the substance.
- Dose descriptor:
- NOAEL
- Effect level:
- 300 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- Remarks on result:
- other: An assessment was undertaken based on available data on the individual constituents of the substance.
- Critical effects observed:
- no
- Conclusions:
- A NOAEL of 300 mg/kg bw/d is proposed for the short-term repeated-dose toxicity of 2-ethylhexanoic acid, compound with 2-aminoethanol (1:1) via the oral route.
- Executive summary:
An assessment was undertaken based on available data on the individual constituents of the substance. A NOAEL of 300 mg/kg bw/d is proposed for the short-term repeated-dose toxicity of 2-ethylhexanoic acid, compound with 2-aminoethanol (1:1) via the oral route. This value is considered as conservative. The substance does not induce specific target organ toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 300 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Justification for classification or non-classification
An assessment was performed based on the properties of the constituents of 2-ethylhexanoic acid, compound with 2-aminoethanol (1:1). None of these constituents is classified as hazardous following a repeated exposure there the registered substance should not be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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