Registration Dossier
Registration Dossier
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EC number: 943-730-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
There are no ecotoxicological data available for Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids. Therefore, read-across to the structurally related substances Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9), Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3), Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2), Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9), and Triisononanoic acid, triester with 2,2’-[oxybis(methylene)]bis[2-(hydroxymethyl)propane-1,3-diol] tris(2-ethylhexanoate) (CAS 68443-84-5) was conducted in order to fulfil the standard information requirements in compliance with Annex XI, 1.5, of Regulation (EC) No 1907/2006. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered as suitable representatives for the assessment of the short-term toxicity to fish, short and long-term toxicity to aquatic invertebrates, toxicity to algae and toxicity to microorganisms of the target substance. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
All experimental studies available for the source substances were performed according to internationally accepted guidelines.
The short-term toxicity to fish was determined in studies according to OECD guideline 203 for the source substances Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9), Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3), Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2), Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9). No effects within the limit of water solubility (1.5 - 5.1 mg/L) are expected.
The short-term toxicity to aquatic invertebrates was determined to OECD guideline 202 for the source substances Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9), Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2), Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9). The same was recorded for the long-term toxicity to aquatic invertebrates. The toxicity to algae was determined according to OECD 201 using the source substances Dipentaerythritol with fatty acids, C5 and C9 iso (CAS 647028-25-9). For all aquatic toxicity studies no effect within the limit of water solubility (1.5 - 5.1 mg/L) are expected.
The activated sludge respiration inhibition test according to OECD 209 with the respective source substances did not show any effects up to a concentration of 1000 mg/L. The test with the source substance Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) according to ISO 10712 did not show any effects up the highest test concentration of 50 mg/L as well.
In conclusion, Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids is not expected to exhibit effects to aquatic organisms up to the water solubility limit.
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