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Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Remarks:
Summary of available data used for the endpoint assessment of the target substance
Adequacy of study:
key study
Justification for type of information:
Refer to analogue justification document provided in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Parameter:
% degradation (CO2 evolution)
Value:
12.1
Sampling time:
23 d
Remarks on result:
other: source, CAS 68443-84-5,Nyco, 2012, CO2 evolution, RL1
Parameter:
% degradation (CO2 evolution)
Value:
18.5
Sampling time:
29 d
Remarks on result:
other: source, CAS 68443-84-5,Nyco, 2012, CO2 evolution, RL1
Parameter:
% degradation (CO2 evolution)
Value:
28
Sampling time:
60 d
Remarks on result:
other: source, CAS 68443-84-5,Nyco, 2012, CO2 evolution, RL1
Parameter:
% degradation (CO2 evolution)
Value:
4.6
Sampling time:
60 d
Remarks on result:
other: source, CAS 84418-63-3, Nyco, 2012, CO2 evolution, RL2
Parameter:
% degradation (CO2 evolution)
Value:
14
Sampling time:
28
Remarks on result:
other: source, CAS 647028-25-9, Croda, 2012, CO2 evolution, RL2
Validity criteria fulfilled:
yes
Interpretation of results:
under test conditions no biodegradation observed

Description of key information

Not readily biodegradable: 4.6 - 28 % (CO2 evolution) in 60 days; read-across.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

No study investigating the biodegradation of Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Triisononanoic acid, triester with 2,2’-[oxybis(methylene)]bis[2- (hydroxymethyl)propane- 1,3-diol] tris(2-ethylhexanoate) (CAS 68443-84-5), Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) and Dipentaerythritol with fatty acids, C5 and C9 iso (CAS 647028-25-9) is applied.

Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered to be suitable representatives for the evaluation of the biodegradation of the target substance. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The biodegradability of Triisononanoic acid, triester with 2,2’-[oxybis(methylene)]bis[2- (hydroxymethyl)propane- 1,3-diol] tris(2-ethylhexanoate) (CAS 68443-84-5), Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) and Dipentaerythritol with fatty acids, C5 and C9 iso (CAS 647028-25-9) was tested in a GLP guideline study following the specifications given by OECD guideline 301 B. The studies were conducted under aerobic conditions using domestic activated sludge as inoculum. During the incubation time of 60 and 28 days the degradation was followed by determining the CO2 production. A degradation rate of 28% was determined at test termination (60 days) for Triisononanoic acid, triester with 2,2’-[oxybis(methylene)]bis[2-(hydroxymethyl)propane- 1,3-diol] tris(2-ethylhexanoate) (CAS 68443-84-5), 4.6% at test termintation (60 days) for Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) and 14% after 28 days for Dipentaerythritol with fatty acids, C5 and C9 iso (CAS 647028-25-9), respectively. None of the source substancesis therefore considered as readily biodegradable according to the OECD criteria.

Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar environmental fate profile and comparable structure, it can be concluded that Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids) is not readily biodegradable.

[Type of water: freshwater]