Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N-acetylhexanelactam
EC Number:
217-565-6
EC Name:
N-acetylhexanelactam
Cas Number:
1888-91-1
Molecular formula:
C8H13NO2
IUPAC Name:
N-acetylhexanelactam
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Danio rerio (HAMIL TON-BUCHANAN)
Breeding at test facility
mean length: 3.0 cm (2.8-3.2 cm)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h

Test conditions

Test temperature:
21.4-21.6°C
pH:
7.2-7.9
Dissolved oxygen:
5.8-9.3
Nominal and measured concentrations:
0, 1000 mg/L
Reference substance (positive control):
no

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
1 000 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
In the control and the limit concentration of 1000 mg/L no mortality occured. Exposed fish showed symptoms.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The acute fish toxicity of the registration substance was tested in a study according to OECD203 resulting in a NOEC (96h) of 1000 mg/L and a LC50 (96h)>1000mg/L.
Executive summary:

The acute fish toxicity of the registration substance was tested in a study according to OECD203 resulting in a NOEC (96h) of 1000 mg/L and a LC50 (96h)>1000mg/L.