Sulpiride

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

(Q)SAR

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited

Data source

Reference

Reference Type:

other: QSAR model

Title:

Developmental Toxicity model (CAESAR) 2.1.7

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Test material information

Constituent 1

Reference substance name:

Sulpiride

EC Number:

239-753-7

EC Name:

Sulpiride

Cas Number:

15676-16-1

Molecular formula:

C15H23N3O4S

IUPAC Name:

sulpiride

Specific details on test material used for the study:

This endpoint has been predicted by a QSAR model for sulpiride (instead of sulpiride HCl) as salts are not included in the applicability domain of QSAR models. Sulpiride and sulpiride HCl are expected to be similar for this endpoint.

Examinations

Statistics:

The applicability domain of predictions is assessed using an Applicability Domain Index (ADI) that has values from 0 (worst case) to 1 (best case). The ADI is calculated by grouping several other indices, each one taking into account a particular issue of the applicability domain. Most of the indices are based on the calculation of the most similar compounds found in the training and test set of the model, calculated by a similarity index that consider molecule's fingerprint and structural aspects (count of atoms, rings and relevant fragments).
For each index, including the final ADI, three intervals for its values are defined, such that the first interval corresponds to a positive evaluation, the second one corresponds to a suspicious evaluation and the last one corresponds to a negative evaluation.

List of indices:
- Similar molecules with known experimental value.
- Accuracy of prediction for similar molecules.
- Concordance for similar molecules.
- Atom Centered Fragments similarity check.
- Model descriptors range check.
- Global AD Index.

Results and discussion

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Toxic to development.

Any other information on results incl. tables

The result appears non-reliable as the predicted compound is outside the applicability domain of the model.

Applicant's summary and conclusion

Conclusions:

The substance is predicted to be toxic to development.