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EC number: 945-888-9 | CAS number: -
The release of ytterbium, zirconium or hafnium from the target substance Ytterbium stabilized Zirconium and Hafnium Oxide in simulated body fluids indicated that the bio-accessibility is very low for all routes (see section 7.1.1). The hafnium release was below the detection limit, the zirconium release was 0.02 µg/mL and the ytterbium release was 3.24 µg/mL from the target substance within 24 hours in artificial perspiration fluid. Thus, the bioavailability of hafnium, zirconium and/or ytterbium after administration to the skin can expected to be very low. No information was found in the public domain, which would have indicated any skin sensitising properties of hafnium, zirconium and/or ytterbium. Based on the results and in line with the 3R principles, the study is scientifically unjustified.
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