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EC number: 945-888-9 | CAS number: -
In a primary eye irritation study conducted according to OECD guideline 492, 50 mg of Ytterbium stabilized Zirconium and Hafnium Oxide (Purity >99.5%) was applied topically on EpiOcular tissue, a reconstituted three-dimensional human corneal epithelium modelfor 6 h and a post-treatment period of 18 h compared to that of the concurrent negative control. Irritation was scored by the method of mean relative tissue viability.
The mean relative tissue viability (% negative control) was > 60% (60.2%). As the results were within the borderline values (60 ± 5%), a second experiment was performed to confirm the first results. The mean relative tissue viability (% negative control) of the second experiment was > 60% (99.2%) and the test item did not show irritant effects. Based on these results, the test item can be classified as a non-irritant according to the UN GHS Criteria.
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