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EC number: 947-998-2 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Test organisms (species):
- Alburnus albidus costa
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (aqueous solution)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Recalculated for target (aqueous solution with a solid content of approximately 95%)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: expressed as solid content
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Nominal concentration of the aqueous solution (mg/L)
Cumulative mortality
0h
6h
24h
48h
72h
96h
0
0/10
0/10
0/10
0/10
0/10
0/10
1.0
0/10
0/10
0/10
0/10
0/10
0/10
1.4
0/10
0/10
0/10
0/10
0/10
0/10
2.0
0/10
0/10
0/10
0/10
0/10
0/10
2.8
0/10
0/10
0/10
0/10
0/10
0/10
5.6
0/10
0/10
0/10
2/10
2/10
5/10
8.0
0/10
0/10
7/10
10/10
10/10
10/10
11.0
0/10
0/10
10/10
10/10
10/10
10/10
Results on the analytical monitoring:
Basisanalysis: 465.5 mg DOC/g test material (aqueous solution)
Nominal concentrations
Measured concentrations in mg DOC/L after:
mg test material (aqueous solution) / L
mg DOC/L
0h (March 9)
24h (March 10)
0h (March 11)
24h (March 12)
1.4
0.65
0.85
1.25
0.95
1.60
2.8
1.30
1.05
1.30
1.35
1.60
8.0
3.72
1.95
2.15
Not measured as all fish were dead
Not measured as all fish were dead
The irrelevance of the DOC measurements is supported by the fact that the measurements at t=0 are higher than the nominal DOC values as well as by the fact that DOC values increase during the test (which is easily understandable as biological activity probably causes this increase).
- Validity criteria fulfilled:
- yes
- Remarks:
- there were no mortalities in the control, the dissolved oxygen concentrations were >60%, the test conditions were stable and the concentration of the substance has been satisfactorily maintained
- Conclusions:
- In a 96h acute toxicity test in fish with Dehyton W (Amphoacetates C12), an LC50 of 1.6 mg/L (expressed as solid content) was determined. This result is read across to Amphoacetates C8-C10.
- Executive summary:
An acute toxicity test with Dehyton W (Amphoacetates C12) was conducted with Brachydanio rerio similar to OECD 203. The test type was semi-static and for 3 test solutions there was analytical monitoring during the 1st and 3rd 24h-exposure period. The report lacks important study design details, especially about the used fish (length and weight). Also no accurate monitoring of the test concentrations. All the validity criteria can be verified and are fulfilled. The 96h-LC50 of the substance was determined to be 1.6 mg/L (expressed as solid content). This result is read across to Amphoacetates C8 -C10.
Reference
Description of key information
In a 96h acute toxicity test in fish, a LC50 of 1.6 mg/L was determined for a substance analogue. This result is read across to Amphoacetates C8-C10.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.6 mg/L
Additional information
An acute toxicity test with Dehyton W (Amphoacetates C12) was conducted with Brachydanio rerio similar to OECD 203. The test type was semi-static and for 3 test solutions there was analytical monitoring during the 1st and 3rd 24h-exposure period. The report lacks important study design details, especially about the used fish (length and weight). Also no accurate monitoring of the test concentrations. All the validity criteria can be verified and are fulfilled. The 96h-LC50 of the substance was determined to be 1.6 mg/L (expressed as solid content). This result is read across to Amphoacetates C8-C10.
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