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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

Key study:- Hooftman & de Wolf (2004), OECD 202 and EU method C.2; EC50>water solubility 
EC50 > 0.21 mg/L( geometric mean of the solubility of the test substance.)
Aqueous solubility of the test material is between 0.09 and 0.54 mg/L.

Key value for chemical safety assessment

Additional information

The data requirement was addressed by the key study Hooftman & de Wolf (2004). The study was performed to GLP and in line with the OECD guideline 202 and EU method C.2. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality in line with Klimisch (1997). The study was considered reliable and adequate for assessment of the test substance. Under the conditions of the test, the EC50 of the test substance was found to be greater than the water solubility of the test substance.

Supporting information was available in the form of Rufli (1988). The study was performed to the OECD guideline 202. However the observations performed during the study did not extend past the 24 hour period, with no explanation as to why the 48 hour observation was not performed. The study lacked details in the reporting in some areas and some deficiencies were present in the performance of the test, such as the test concentrations were not maintained throughout the entire test period. As such the study was assigned a reliability score of 2 in line with the principles of assigning data quality as outlined in Klimisch (1997). As the results of the study confirmed the lack of toxicity observed in the more reliable key study, the study was considered reliable with restrictions and suitable as supporting information to the key study. Under the conditions of the test, the EC50 of the test substance in Daphnia magna was determined to be greater than the water solubility of the test substance.