Registration Dossier

Administrative data

Endpoint:
dissociation constant
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance is hydrolytically unstable (half-life less than 12 hours)
Cross-reference
Reason / purpose:
reference to other study
Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
yes
Remarks:
see free text
Principles of method if other than guideline:
a) additional pH 1.2
b) only pre-study, based on hydrolysis at once; t(1/2) < 5 min
GLP compliance:
no
Radiolabelling:
no
Analytical monitoring:
yes
Duration:
5 min
pH:
1.2
Temp.:
20 °C
Initial conc. measured:
0.1 mol/L
Remarks:
visible hydrolysis at once
Duration:
5 min
pH:
4
Temp.:
20 °C
Initial conc. measured:
0.1 mol/L
Remarks:
visible hydrolysis at once
Duration:
5 min
pH:
7
Temp.:
20 °C
Initial conc. measured:
0.1 mol/L
Remarks:
visible hydrolysis at once
Duration:
5 min
pH:
9
Temp.:
20 °C
Initial conc. measured:
0.1 mol/L
Remarks:
visible hydrolysis at once
Positive controls:
no
Negative controls:
no
Preliminary study:
xes, visible hydrolysis at once
Transformation products:
yes
No.:
#1
No.:
#2
pH:
1.2
Temp.:
20 °C
Duration:
5 min
Remarks on result:
not determinable because of methodological limitations
Remarks:
very low solubility
pH:
4
Temp.:
20 °C
Duration:
5 min
Remarks on result:
not determinable because of methodological limitations
pH:
7
Temp.:
20 °C
Duration:
5 min
Remarks on result:
not determinable because of methodological limitations
pH:
9
Temp.:
20 °C
Duration:
5 h
Remarks on result:
not determinable because of methodological limitations
Key result
pH:
1.2
Temp.:
20 °C
DT50:
< 5 min
Type:
not specified
Remarks on result:
not determinable because of methodological limitations
Remarks:
based on solubility
Key result
pH:
4
Temp.:
20 °C
DT50:
< 5 min
Type:
not specified
Remarks on result:
not determinable because of methodological limitations
Remarks:
based on solubility
Key result
pH:
7
Temp.:
20 °C
DT50:
< 5 min
Type:
not specified
Remarks on result:
not determinable because of methodological limitations
Remarks:
based on solubility
Key result
pH:
9
Temp.:
20 °C
DT50:
< 5 min
Type:
not specified
Remarks on result:
not determinable because of methodological limitations
Remarks:
based on solubility
Validity criteria fulfilled:
yes
Conclusions:
dioctyltin di(acetat) hydrolysis at once in contact with water in high molar DOTO / dimeric stannoxane compelex and ehtanol

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion