Allyl isothiocyanate

Stability in organic solvents and identity of relevant degradation products

Link to relevant study record(s)

Reference

Endpoint:

stability in organic solvents and identity of relevant degradation products

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

Allyl Isothiocyanate displays excellent solubility in ethanol.
0.5 ml each of a mixture of Allyl Isothiocyanate and ethanol were mixed thoroughly in sealed bottles and stored for two weeks at 4, 28 or 40°C.
Allyl Isothiocyanate content was measured by Gas Chromatography after one day and again after two weeks of storage.
The sample stored at 4°C was kept in storage until the sixth month, when its composition was analyzed by GC/MS.

GLP compliance:

not specified

Specific details on test material used for the study:

Allyl Isothiocyanate purity: 99.9%

Test substance stable:

no

Transformation products:

yes

No.:

#1

In the presence of ethanol, Allyl Isothiocyanate decomposed more rapidly. When stored at 40°C, about 15% decomposed in 2 weeks. Even at 4°C, measurement by GC/MS showed that ethyl allyl thiocarbamate had formed over 26% of the surface area after 6 months of storage

 

Stability of Allyl Isothiocyanate in ethanol:

	Residual level (%)
Storage temperature	Initial	1 day	2 weeks
4°C	100	100	99.3
28°C	100	99.3	91.1
37°C	100	97.6	78.0

 

Conclusions:

In the presence of ethanol, Allyl Isothiocyanate produced an additional compound (ethyl allyl thiocarbamate), therefore a mixture of teh test item with ethanol is not feasible as basis for a pratical preparation of Allyl Isothiocyanate.

Description of key information

In the presence of ethanol, Allyl Isothiocyanate produced an additional compound (ethyl allyl thiocarbamate).