(2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)triethane-2,1-diyl tris(3-mercaptopropionate)

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

not specified

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)

Deviations:

not specified

GLP compliance:

not specified

Remarks:

the test was conducted in an academic setting without GLP certification

Oxygen conditions:

aerobic

Inoculum or test system:

sewage, predominantly domestic, non-adapted

Details on inoculum:

- Source of inoculum/activated sludge: STP of Lüneburg, Germany (144,000 inhabitant
equivalents)
- Initial cell/biomass concentration: two drops of effluent per L

Duration of test (contact time):

28 d

Key result

Parameter:

% degradation (O2 consumption)

Sampling time:

28 d

Remarks on result:

other: please see table below for measured O2 consumption values

Biodegradation test results obtained in the present study. For each experiment the % O₂consumption in the two parallel bottles is given, and for valid results the average ±SD, otherwise the criterion rendering a result invalid.

Compound name (abbreviation) [CAS-RN]	Experiment number	OECD 301D (CBT)		OECD 301F (MRT)
		O2Consumption/ ThOD [%]	Average in a valid experiment ±SD	O2Consumption/ ThOD [%]	Average in a valid experiment ±SD
	2*			18.4, 13.9	16.2 ±3.2
3-MPA and derivatives
3-Mercaptopropionic acid (3-MPA) [107-96-0]	1	0.4, 32.4	not valid, criterion 1	78.7, 87.0	82.8 ±5.9
	2	27.4, -7.3	not valid, criteria 1 and 4	101.4, 90.1	95.8 ±8.0
	3	0.6, 3.8	2.2 ±2.3
Dithiodipropionic acid (DTDPA, 3-MPA disulfide) [1119-62-6]	1	3.9, 1.5	2.7 ±1.7	121.6, 87.9	not valid, criterion 1
	2			93.7, 100.3	97.0 ±4.7
Methyl 3-mercaptopropionate (MMP) [2935-90-2]	1	65.0, 61.7	63.4 ±2.3	23.3, 12.0	17.7 ±8.0
	2	16.0, 21.0	18.5 ±3.6
	3	74.1, 14.1	not valid, criterion 1
	4	5.4, 12.3	8.8 ±4.9
Propanoic acid, 3,3'-dithiobis-, dimethyl ester (MMP disulfide) [15441-06-2]	1	6.6, 4.1	5.4 ±1.8	61.6, 84.2	not valid, criterion 1
	2	10.6, 13.0	11.8 ±1.7	14.0, 21.7	17.8 ±5.4
	3*			21.6, 1.3	not valid, criterion 1
Butyl 3-mercaptopropionate (BuMP) [16215-21-7]	1	55.6, 29.0	not valid, criterion 1	15.0, 20.7	17.8 ±4.0
	2	57.4, 60.3	not valid, criterion 4
	3	61.9, 62.5	62.2 ±0.5
	4	40.8, 41.1	41.0 ±0.2
2-Ethylhexyl 3-mercaptopropionate (2-EHMP) [50448-95-8]	1*	54.3, 49.8	52.1 ±3.2	56.4, 27.0	not valid, criterion 1
	2*			42.4, 51.6	47.0 ±6.5
Isooctyl 3-mercaptopropionate (iOMP) [30374-01-7]	1**	31.1, 32.1	31.6 ±0.8	-8.2, 4.6	-1.8 ±9.0
Isotridecyl 3-mercaptopropionate (iC13MP)^a [1040871-35-9]	1**	10.5, 17.6	14.1 ±5.0	29.5, -11.1	not valid, criterion 1
	2**			34.2, 35.8	35.0 ±1.2
Glycol di(3-mercaptopropionate) (GDMP) [22504-50-3]	1	2.1, -0.8	0.7 ±2.0	73.4, 39.8	not valid, criterion 1
	2	10.4, 13.6	12.0 ±2.3	32.8, 50.4	41.6 ±12.5
	3*			33.4, 41.0	37.2 ±5.3
Trimethylolpropane tris(3-mercapto-propionate)^a(TMPMP) [33007-83-9]	1**	8.2, 9.9	9.1 ±1.2	32.9, 55.4	not valid, criterion 1
	2**			4.7, 1.7	3.2 ±2.1
Dipentaerythrityl hexakis(3-mercaptopropionate)^a(DiPETMP) [25359-71-1]	1**	1.4, 3.3	2.4 ±1.4	14.8, 42.4	not valid, criterion 1
	2**			12.0, -5.5	3.2 ±12.3
Ethoxylated trimethylolpropane tris(3-mercaptopropionate)^a (ETTMP 700) [674786-83-5 or 345352-19-4]	1**	3.1, -3.2	not valid, criterion 4	35.1, 40.0	37.6 ±3.5
	2**	9.2, 8.6	8.9 ±0.5

^amulticonstituent substance (MCS), for details see Experimental

^bresult from one test bottle only, the other one became leaky during the experiment

^*due to poor solubility, this substance was directly weighed in MRT

^**due to very poor solubility, this substance was directly weighed both in CBT and MRT

 

Validity criteria fulfilled:

yes

Interpretation of results:

inherently biodegradable

Remarks:

Based on data with polyvalent sulfyhdyl compounds published in Rücker et al. (2018)..

Conclusions:

The substance TEMPIC is considered to be inherently biodegradable

Description of key information

Based on read-across from related mercaptopropionates, TEMPIC is predicted to be not readily biodegradable. However, the predicted biodegradation exceeds 20% and TEMPIC is thus assumed to be inherently biodegradable.

Key value for chemical safety assessment

Biodegradation in water:

inherently biodegradable

Type of water:

freshwater