Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
flash point of flammable liquids
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the flash point is only relevant to liquids and low melting point solids
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 27, 2012 - September 18, 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study (OECD102) with acceptable restrictions
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
GLP compliance:
no
Type of method:
thermal analysis
Decomposition:
yes
Decomp. temp.:
>= 180 °C

In all three measurements a broad exothermal effect could be observed in a temperature range of 190 – 360 °C with a decomposition energy of -190 J/g (mean value). In all three measurements a mass loss of approximately 68 % could be observed.

Table: Results on melting and boiling point

No.

Sample weight / mg

Start of effect / °C

Energy /
J/g

Remark

PN4233

13.94

200

-190 (exothermal)

PN4242

10.58

210

-170 (exothermal)

PN4262

12.04

190

-210(exothermal)

Conclusions:
According to OECD Test Guidelines 102 and 103, and EC No. 440/2008 Part A. Method A.1. and A.2., the test item 7-Aminocephalosporanic acid has no melting and no boiling point at atmospheric pressure (1013 hPa). It decomposes firstly at a temperature of 180 °C.
Executive summary:

According to OECD Test Guidelines 102 and 103, and EC No. 440/2008 Part A. Method A.1. and A.2., the test item 7-Aminocephalosporanic acid has no melting and no boiling point at atmospheric pressure (1013 hPa). It decomposes firstly at a temperature of 180 °C.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion