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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
No data on test method. No GLP.

Data source

Reference
Reference Type:
publication
Title:
Ueber das Schicksal cyklischer Terpene und Campher im thierischen Organismus. Dritte Mittheilung: Ueber das Verhalten des Camphers im Thierkörper.
Author:
Fromm E
Year:
1903
Bibliographic source:
Zeitschrift für Physiologische Chemie 37: pp. 189-202

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
The metabolism of Camphene was studied on rabbits. The test substance was administered by gavage, with olive oil as vehicle.
No more data provided on the method.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(1R)-2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane
EC Number:
227-336-2
EC Name:
(1R)-2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane
Cas Number:
5794-03-6
Molecular formula:
C10H16
IUPAC Name:
(1R)-2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Duration and frequency of treatment / exposure:
No data
No. of animals per sex per dose / concentration:
No data
Control animals:
not specified
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled (delete / add / specify): urine (as fresh as possible)

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Camphene was the only studied terpene in rabbits that produced glucuronic acid as a metabolite in the urine.

Any other information on results incl. tables

Camphene was the only studied terpene in rabbits that produced glucuronic acid as a metabolite in the urine.

Applicant's summary and conclusion

Conclusions:
Camphene was the only studied terpene in rabbits that produced glucuronic acid as a metabolite in the urine.
Executive summary:

The metabolism of camphene was studied on rabbits. The test substance was administered by gavage, with olive oil as vehicle. Camphene was the only studied terpene in rabbits that produced glucuronic acid as a metabolite in the urine.