Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vivo, other
Remarks:
Drosophila Mutagenicity Assay
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 477 (Genetic Toxicology: Sex-linked Recessive Lethal Test in Drosophila melanogaster)
GLP compliance:
not specified
Remarks:
Not applicable ( prior to 1981)
Type of assay:
other: Drosophila mutagenesis assay

Test material

Constituent 1
Reference substance name:
Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
EC Number:
915-680-2
Molecular formula:
not applicable for UVCB
IUPAC Name:
Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate

Test animals

Species:
other: Drosophila Mutagenicity
Strain:
not specified
Sex:
not specified

Administration / exposure

Details on exposure:
Initial experimentation determined that adults could be effectively treated by confinement in a bottle with a filter papier which was saturated with the substance.
Duration of treatment / exposure:
4-hour treatment results in 30-40% mortality. Larvae were treated by placing them directly on such a wick for 30 minutes.
Control animals:
not specified

Examinations

Details of tissue and slide preparation:
A 4-hour treatment results in 30-40% mortality. Larvae were treated by placing them directly on such a wick for 30 minutes.

Results and discussion

Test results
Key result
Sex:
not specified
Genotoxicity:
not specified

Applicant's summary and conclusion

Conclusions:
This one dose treatment did not significantly increase the frequency of exceptions over control values in any of the assays performed in Drosophila melanogaster under the experimental conditions used.
Executive summary:

This one dose treatment did not significantly increase the frequency of exceptions over control values in any of the assays performed in Drosophila melanogaster under the experimental conditions used.

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