(3E)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

31 August 2017 - 05 September 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

1.08 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

5 - 6

Details on results:

According to the test guideline five consecutive samples should not differ in concentration by more than ±30 % and the mean values obtained from two tests with different flows should not differ by more than 30 %. These criteria were fulfilled and therefore, the study is valid.

Table 1. Results for the determination of water solubility

Test number	Flow rate (mL/h)	Water solubility (mg/L)
1	41	1.11
1	41	0.888
1	41	1.19
1	41	1.14
1	41	1.02
Average of test 1	41	1.07 ± 0.12
2	21	0.909
2	21	1.17
2	21	0.895
2	21	1.15
2	21	1.30
Average of test 2	21	1.09 ± 0.18
Average of tests 1 and 2	-	1.08 ± 0.15

Conclusions:

The water solubility of the test item was found to be 1.08 ± 0.15 mg/L at 20 °C.

Executive summary:

The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6). The study was conducted according to OECD Method 105 and was GLP-compliant, therefore it is considered to be reliable without restriction (Klimisch 1).

Description of key information

The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6).

Key value for chemical safety assessment

Water solubility:

1.08 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6) (2017). The study was conducted according to OECD Method 105 and was GLP-compliant, therefore it is considered to be reliable without restriction (Klimisch 1).