Registration Dossier
Registration Dossier
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EC number: 224-160-8 | CAS number: 4219-49-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects to aquatic algae up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity to aquatic invertebrates of 2-Hydroxyethyl Palmitate (CAS 4219-49-2)
are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to the structurally related category member Fatty acidds, C16 -C18, esters with ethylene glycol (CAS 91031-31-1) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The toxicity of fatty acids, C16-18, esters with ethylene glycol (CAS 91031-31-1) was investigated according to DIN 38412-9 under GLP conditions (Stelter, 1994). The green algae Scenedesmus subspicatus was exposed to nominal concentrations of 10 and 100 mg/L without a further filtration step. No inhibition of growth of S. subspicatus up to the limit of water solubility was observed resulting in an EC50 > 100 mg/L. An EC10 of 34 mg/L was determined since growth stimulation was observed in both concentrations used in this study. No inhibition of growth was observed. It can be concluded that fatty acids, C16-18, esters with ethylene glycol will not exhibit effects to aquatic algae up to the limit of water solubility, nor its structural analog 2 -hydroxyethyl palmitate.
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