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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

No short-term toxicity effects on fish up to the limit of water solubility

Key value for chemical safety assessment

Additional information

For Fatty acids, C18 -22 (CAS 90990 -11 -7), which contains as main constituents C18 with a content of 1 -40%, C20 with a content of 10 -65% and C22 with a content of 20 -50% one study on fish is available, which is chosen as key study. In addition to the available study, read-across is performed to studies conducted with the pure homologues stearic acid C18 (CAS 57 -11 -4) and docosanoic acid C22 (CAS 112 -85 -6) to support the results of the test with the fatty acids C18 -22.

Fatty acid homologue

LC50(as reported in the study)

Water solubility*

Test design and species

Reference

fatty acids, C18 - C22

> 1000 mg/L (nominal)

< 0.6 mg/L at 25 °C

96 h, semi-static,
Danio rerio

Richterich and Mühlberg, 2001a

docosanoic acid C22

> 5 mg/L (nominal)

0.016 mg/L (insoluble)

96 h, semi-static, solvent used,
Oryzias latipes

MOE, 1997

stearic acid C18

> 10000 mg/L (nominal)

< 0.05 mg/L (insoluble)

48 h, static, Leuciscus idus

Richterich and Mühlberg, 2001b

 * see category justification

The C18 -22 fatty acid mixture (CAS 90990 -11 -7) was tested on zebrafish (Danio rerio) over a period of 96 h (Richerich and Mühlberg, 2001a). The non-GLP semi-static test was conducted accordig to ISO 7346 -1 (which is equivalent to OECD 203). No effects on fish up to the highest test concentration are reported resulting in a LC50 -value above 1000 mg/L.

The study available for docosanoic acid C22 was conducted by the Ministry of the Environment, Government of Japan (1998) according to OECD 203 and in accordance with GLP requirements. Medaka (Oryzias latipes) were exposed to docosanoic acid under semi-static conditions in a limit test. Since no mortality was observed during the exposure period the LC50 (96 h) was determined to be > 5.0 mg/L based on nominal concentrations. Thus no effects could be observed within the range of water solubility, which is determined to be 0.016 mg/L.

The homologue stearic acid C18 was tested on golden orfe (Leuciscus idus) (Richterich and Mühlberg, 2001b). In the static test, which was conducted according to DIN 38412/15, the fish were exposed to different concentrations of the test substance (1000, 3000, 10000 mg/L nominal) within an exposure period of 48 h. In the study no effects on fish were reported, resulting in a LC50 > 10000 mg/L.

Considering the results reported for fatty acids, C18 - 22 and the pure homologues C18 and C22 no toxicity within the range of water solubility is to be expected for fatty acids, C18-22.