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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Reference
Reference Type:
publication
Title:
Neomenthol
Author:
World Health Organization
Year:
1999
Bibliographic source:
World Health Organization

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity of (+)-Neomenthol (CAS no: 2216-52-6) in mice.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: (+)-Neomenthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9) 11/h7-11H,4-6H2,1-3H3/t8-,9+,10+/m1/s1- Smiles: C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C- Name of test material (as cited in study report):d-Neomenthol- Molecular formula :C10H20O- Molecular weight:156.267 g/mol- Substance type:Organic
Specific details on test material used for the study:
- IUPAC Name: (+)-Neomenthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9) 11/h7-11H,4-6H2,1-3H3/t8-,9+,10+/m1/s1- Smiles: C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C- Name of test material (as cited in study report):d-Neomenthol- Molecular formula :C10H20O- Molecular weight:156.267 g/mol- Substance type:Organic

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
4000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed in treated mice.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be 4000 mg/kg bw, when mice were treated with (+)-Neomenthol (CAS no: 2216-52-6) via oral route.
Executive summary:

Acute oral toxicity study of (+)-Neomenthol (CAS no: 2216-52-6) was conducted in mice at the dose concentration of 4000 mg/kg bw. 50% mortality was observed in treated mice. Hence, LD50 value was considered to be 4000 mg/kg bw, when mice were treated with(+)-Neomentholvia oral route.