(R)-quinuclidin-3-ol

Guidance on Safe Use

First-aid measures

Eye Contact: Flush with copious quantities of water or saline, including under eyelids for at least 15 minutes

Skin Contact: Wash affected area with soap and water. Remove contaminated clothing. Seek medical attention if reaction occurs/persists.       

Inhalation: Remove promptly to fresh air. If not breathing, administer artificial respiration. Administer oxygen if breathing is difficult.

Ingestion: Do not induce vomiting. Seek medical advice if adverse reaction occurs and persists.

Most important symptoms and effects, both acute and delayed

Risks: Harmful if swallowed, Skin sensitizer

Fire-fighting measures

Suitable extinguishing media: Carbon dioxide, Dry powder, water or foam extinguisher

Known hazards arising from combustion: None known but likely to emit harmful oxides of Carbon and nitrogen

Advice for firefighters: Wear self-contained breathing apparatus, suitable protective clothing and chemical resistant gloves

Accidental release measures

Personal Protection in case of large spill: A self contained breathing apparatus should be used to avoid inhalation of the product. Suitable protective clothing and chemical resistant gloves required.

Environmental precautions: Avoid contamination of surface waters. Cover drains.

Methods and materials for containment and cleaning up: Vacuum or sweep up material and place into suitable dedicated UN approved drum. Use non sparking tools.

Handling and storage

Handling: Use process enclosure (e.g. glove-box units), local exhaust ventilation or other suitable engineering controls to control airborne levels. Charge slowly into vessels to minimize dust clouds. Use slow controlled movements for scooping from one container to another where applicable. Sweep up/ wet down material and place into suitable UN approved disposal container.

Avoid contact with skin and eyes. Avoid inhaling dusts. Ensure emergency eyewash equipment is close by.

General Occupational Hygiene: Do not to eat, drink and smoke in work areas;

Wash hands after use; and remove contaminated clothing and protective equipment before entering

eating areas.

Storage: Material should be stored in static dissipative bags in well ventilated areas at about 25oC in closed containers

Specific use(s): Ensure adequate earthing of equipment. Avoid ignition sources including static. Ensure adequate earthing of personnel including footwear and gloves and work on a static dissipative floor.

Transport information

Shipping

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Shipping

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Marine transport (UN RTDG/IMDG)

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Shipping

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Exposure controls / personal protection

Exposure limit values

Internal Occupational Exposure limit set at 0.1 mg/m3 for inhalation exposure. No national occupational exposure limits available.

Sampling will be conducted based on the MDHS 14/4 sampling and analysis method. Samples will be collected onto 25mm filters contained in IOM heads. The filters will be desorbed and analysed using in-house methods for this material developed by IOM Consulting Ltd in Edinburgh.

Exposure controls

Appropriate engineering controls

Dusts of this product should not be breathed in. Engineering methods to prevent or control exposure below the permissible exposure limits should be used. Use process enclosure (e.g. glove-box units), local exhaust ventilation or other suitable engineering controls to control airborne levels.

Personal protective equipment       

Respiratory protection: Wear a suitable respirator designed for achieving a high level of filtration to dust such as powered respirators or full face masks with a P3 filter (EN 14387/ EN143)

Hand protection: Impermeable static dissipative gloves (e.g. nitrile gloves to EN 374-2) with an extended cuff covering part of the forearm) are required as well as donning/doffing training and specific activity training... A degradation tests against this chemical was not run. However since its breakthrough time is expected to be greater than 480minutes (analogy with corrosive 50% caustic, the degradation rating is expected to be good to excellent.

Eye protection: If respirator does not already provide eye protection, wear goggles conforming to EN-166.

Skin protection: Wear Tyvek or similar static dissipative overalls (e.g. to EN13982, EN13034).  If contaminated, must be removed whilst wearing a respirator and disposed off in an appropriate manner. Wear static dissipative footwear and work on a static dissipative floor.

Hygiene Measures       

Handle in accordance with good industrial hygiene and safety practice. Keep away from food and drink. Wash hands (and face where exposed to product) before breaks and immediately if exposure occurs anywhere else on the body.

Environmental exposure controls

Follow onsite trained procedural controls to minimize advertent exposures.

Do not allow material to contaminate the ground water system.

Any unused material/ spilt material to be disposed in UN approved drums.

Stability and reactivity

Reactivity: Stable under normal temperatures and pressures

Chemical Stability: Stable under normal temperatures and pressures

Possibility of hazardous reactions: None known

Conditions to avoid: Generation of dust clouds. Conditions such as static discharge or other physical stresses that might result in a hazardous situation. Careful charging of this material combined with earthing of vessels, tools, floors and workers are essential to avoid such conditions. Avoid sparking tools.

Incompatible materials: None known

Disposal considerations

National, local and EU regulations concerning waste disposal must be respected.

Chemical Neutralisation method:       None known

Methods for recovery/ recycling:       Only for empty non contaminated packaging

Disposal by incineration:       Recommended

Other recommended disposal methods:       Not recommended.