Registration Dossier
Registration Dossier
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EC number: 246-857-6 | CAS number: 25333-42-0
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- GLP compliance:
- yes
- Type of method:
- Laser scattering/diffraction
- Remarks:
- visual microscopic analysis
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- (R)-quinuclidin-3-ol
- EC Number:
- 246-857-6
- EC Name:
- (R)-quinuclidin-3-ol
- Cas Number:
- 25333-42-0
- Molecular formula:
- C7H13NO
- IUPAC Name:
- quinuclidin-3-ol
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 533.736 µm
- Geometric standard deviation:
- 2.349
Particle sizeopen allclose all
- Percentile:
- D10
- Mean:
- 241.869 µm
- St. dev.:
- 1.545
- Percentile:
- D50
- Mean:
- 481.253 µm
- St. dev.:
- 2.118
- Percentile:
- D90
- Mean:
- 892.752 µm
- St. dev.:
- 9.344
Any other information on results incl. tables
The physical characteristics of the material are recorded, noting such items as shape and size distribution.
Standard visual observation = Sample observed to be coarse to medium white crystals.
Observation using 3.2 objective lens = The particles appeared to be irregular shaped crystals. The smallest individual particle size was
approximately 96 μm and the largest individual size was approximately 1152 μm.
Observation using 40 objective lens = The sample was observed to be made up of single crystalline particles.
Applicant's summary and conclusion
- Conclusions:
- The MMAD for the substance was determined to be 533.736 micrometres. 0.00% particles were determined to be <10 micrometres.
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